Evidence map›Paper›PMID 39246489›Full record

ArticleACS omega2024

DNA Damage-Inducing 10-Methoxy-canthin-6-one (Mtx-C) Promotes Cell Cycle Arrest in G

Heron F V Torquato, Manoel Trindade Rodrigues Junior, Cauê Santos Lima, Roberto Theodoro de Araujo Júnior, Caio C S P Soares, André Tarsis Domiciano, Rafael Leite Tavares de Morais, Daiane Rosolen, Luciane Regina Cavalli, Osvaldo Andrade Santos-Filho and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Heron F V TorquatoFaculdade de Ciências Farmacêuticas, Alimentos e Nutrição, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS 79070-900, Brazil.ORCID https://orcid.org/0000-0002-9480-9657
Manoel Trindade Rodrigues JuniorInstituto de Química, Universidade Estadual de Campinas, Campinas, SP 13084-971, Brazil.ORCID https://orcid.org/0000-0001-9230-5642
Cauê Santos LimaDepartamento de Bioquímica, Universidade Federal de São Paulo, R. Três de Maio 100, São Paulo, SP 04044-020, Brazil.
Roberto Theodoro de Araujo JúniorDepartamento de Bioquímica, Universidade Federal de São Paulo, R. Três de Maio 100, São Paulo, SP 04044-020, Brazil.
Caio C S P SoaresInstituto de Química, Universidade Estadual de Campinas, Campinas, SP 13084-971, Brazil.
André Tarsis DomicianoDepartamento de Bioquímica, Universidade Federal de São Paulo, R. Três de Maio 100, São Paulo, SP 04044-020, Brazil.
Rafael Leite Tavares de MoraisDepartamento de Biofísica, Universidade Federal de São Paulo, R. Três de Maio 100, São Paulo, SP 04044-020, Brazil.
Daiane RosolenInstituto de Pesquisa Pelé Pequeno Príncipe, Curitiba 80250-060, Brazil.
Luciane Regina CavalliInstituto de Pesquisa Pelé Pequeno Príncipe, Curitiba 80250-060, Brazil.
Osvaldo Andrade Santos-FilhoLaboratório de Modelagem Molecular e Biologia Estrutural Computacional, Instituto de Pesquisas de Produtos Naturais Walter Mors, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho, 373 - Bloco H, Cidade Universitária, Rio de Janeiro 21941-599, Brazil.ORCID https://orcid.org/0000-0001-7407-158X
Giselle Zenker JustoDepartamento de Bioquímica, Universidade Federal de São Paulo, R. Três de Maio 100, São Paulo, SP 04044-020, Brazil.
Ronaldo Aloise PilliInstituto de Química, Universidade Estadual de Campinas, Campinas, SP 13084-971, Brazil.
Edgar J Paredes-GameroFaculdade de Ciências Farmacêuticas, Alimentos e Nutrição, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS 79070-900, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synthetic 10-methoxy-canthin-6-one (Mtx-C), an alkaloid derivative, exhibits cytotoxic effects against acute myeloid cells (AMLs) and leukemic stem cells (LSCs) at a concentration of approximately 60 μM. However, the antitumor mechanism of Mtx-C in AMLs and LSCs remains elusive. Using Mtx-C at concentrations with low cytotoxicity (2-4 μM) for 72 h, we observed cell arrest with the accumulation of cells in the G

Identifiers

PMID39246489
PMCPMC11375717

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.