Evidence map›Paper›PMID 39246441›Full record

ArticleiScience2024

Kaspar Hauser's alleged noble origin - New molecular genetic analyses resolve the controversy.

Walther Parson, Christina Amory, Turi King, Michaela Preick, Cordula Berger, Anna König, Gabriela Huber, Katja Anslinger, Birgit Bayer, Gottfried Weichhold and 7 more

Abstract read
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Walther ParsonInstitute of Legal Medicine, Medical University of Innsbruck, Innsbruck, Austria.
Christina AmoryInstitute of Legal Medicine, Medical University of Innsbruck, Innsbruck, Austria.
Turi KingDepartment of Life Sciences, Milner Centre for Evolution, University of Bath, Bath, UK.
Michaela PreickEvolutionary Adaptive Genomics, University of Potsdam, Potsdam, Germany.
Cordula BergerInstitute of Legal Medicine, Medical University of Innsbruck, Innsbruck, Austria.
Anna KönigInstitute of Legal Medicine, Medical University of Innsbruck, Innsbruck, Austria.
Gabriela HuberInstitute of Legal Medicine, Medical University of Innsbruck, Innsbruck, Austria.
Katja AnslingerInstitute of Legal Medicine, Ludwig-Maximilians-University, Munich, Germany.
Birgit BayerInstitute of Legal Medicine, Ludwig-Maximilians-University, Munich, Germany.
Gottfried WeichholdThermo Fisher Scientific, Munich, Germany.
Timo SängerInstitute of Forensic Medicine, Medical Center, University of Freiburg and Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Sabine Lutz-BonengelInstitute of Forensic Medicine, Medical Center, University of Freiburg and Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Heidi PfeifferInstitute of Legal Medicine, University Hospital Münster, Münster, Germany.
Michael HofreiterEvolutionary Adaptive Genomics, University of Potsdam, Potsdam, Germany.
Dietmar PfründerPrivate Scholar, Gaiberg, Germany.
Carsten HohoffInstitute of Legal Medicine, University Hospital Münster, Münster, Germany.
Bernd BrinkmannInstitute of Legal Medicine, University Hospital Münster, Münster, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kaspar Hauser's parentage has been the subject of research and debate for nearly 200 years. As for his possible aristocratic descent through the House of Baden, there is suspicion that he was swapped as a baby, kidnapped, and kept in isolation to bring a collateral lineage to the throne. In the last 28 years, various genetic analyses have been carried out to investigate this possible aristocratic origin. Previous results using less sensitive Sanger and electrophoresis-based methods were contradictory, and moreover, the authenticity of some samples was disputed, thus leaving the question open. Our analyses using modern capture- and whole genome-based massively parallel sequencing techniques reveal that the mitochondrial DNA haplotypes in different samples attributed to Kaspar Hauser were identical, demonstrating authenticity for the first time, and clearly different from the mitochondrial lineage of the House of Baden, which rules out a maternal relationship and thus the widely believed "Prince theory".

Indexed as

HistoryMolecular geneticsTechniques in genetics

Identifiers

PMID39246441
PMCPMC11379569

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.