Evidence map›Paper›PMID 39246425›Full record

ArticleInternational journal of nanomedicine2024

Antiviral Activity of Graphene Oxide-Silver Nanocomposites Against Murine Betacoronavirus.

Joanna Cymerys, Michalina Bartak, Anna Słońska, Agata Lange, Sławomir Jaworski, Marcin Chodkowski, Agnieszka Ostrowska, Mateusz Wierzbicki, Ewa Sawosz, Marcin W Bańbura

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Joanna Cymerys *Department of Preclinical Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, Poland.ORCID 0000-0002-5273-3930
Michalina Bartak *Department of Preclinical Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, Poland.
Anna SłońskaDepartment of Preclinical Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, Poland.
Agata LangeDepartment of Nanobiotechnology, Institute of Biology, Warsaw University of Life Sciences, Warsaw, Poland.ORCID 0000-0003-1523-083X
Sławomir JaworskiDepartment of Nanobiotechnology, Institute of Biology, Warsaw University of Life Sciences, Warsaw, Poland.ORCID 0000-0002-4619-941X
Marcin ChodkowskiMilitary Institute of Hygiene and Epidemiology, Warsaw, Poland.
Agnieszka OstrowskaDepartment of Nanobiotechnology, Institute of Biology, Warsaw University of Life Sciences, Warsaw, Poland.ORCID 0000-0001-8781-6106
Mateusz WierzbickiDepartment of Nanobiotechnology, Institute of Biology, Warsaw University of Life Sciences, Warsaw, Poland.ORCID 0000-0003-3623-8929
Ewa SawoszDepartment of Nanobiotechnology, Institute of Biology, Warsaw University of Life Sciences, Warsaw, Poland.
Marcin W BańburaDepartment of Preclinical Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The high infectivity of coronaviruses has led to increased interest in developing new strategies to prevent virus spread. Silver nanoparticles (AgNPs) and graphene oxide (GO) have attracted much attention in the antiviral field. We investigated the potential antiviral activity of GO and AgNPs combined in the nanocomposite GO-Ag against murine betacoronavirus MHV using an in vitro model. Methods: GO, AgNPs, and GO-Ag characterization (size distribution, zeta potential, TEM visualization, FT-IR, and EDX analysis) and XTT assay were performed. The antiviral activity of GO-Ag nanocomposites was evaluated by RT-qPCR and TCID Results: A significant reduction in virus titer was observed for all nanocomposites tested, ranging from 3.2 to 7.3 log10 TCID Conclusion: Graphene oxide sheets act as a stabilizing agent, inhibiting the accumulation of AgNPs and reducing their cellular toxicity. The GO-Ag composite can physically bind and inhibit murine betacoronavirus from entering cells. Furthermore, the constant presence of GO-Ag can inhibit MHV replication and significantly limit its extracellular release. In conclusion, GO-Ag shows promise as an antiviral coating on solid surfaces to minimize virus transmission and spread.

Indexed as

Antiviral AgentsGraphiteMetal NanoparticlesNanocompositesSilverAnimalsCell LineCoronavirus InfectionsHepatocytesMiceMurine hepatitis virusAntiviral Agentsgraphene oxideGraphiteSilverantiviralcoronavirusGO-Ag compositegraphene oxideMHVsilver nanoparticles

Identifiers

PMID39246425
PMCPMC11380865

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.