Evidence map›Paper›PMID 39246269›Full record

ArticleChemMedChem2024

Cyclodextrin Dimers Functionalized with Biotin as Nanocapsules for Active Doxorubicin Delivery Against MCF-7 Breast Cell Line.

Noemi Bognanni, Chiara Scuderi, Valentina Giglio, Fabio Spiteri, Luana La Piana, Daniele Condorelli, Vincenza Barresi, Graziella Vecchio

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Noemi BognanniDepartment of Chemical Science, University of Catania, Viale A. Doria 6, 95125, Catania, Italy.
Chiara ScuderiDepartment of Biomedical and Biotechnological Sciences, Section of Medical Biochemistry, University of Catania, Via Santa Sofia 89, 95123, Catania, Italy.
Valentina GiglioInstitute of Biomolecular Chemistry CNR-ICB, Via Paolo Gaifami 18, 95125, Catania, Italy.
Fabio SpiteriDepartment of Chemical Science, University of Catania, Viale A. Doria 6, 95125, Catania, Italy.
Luana La PianaDepartment of Chemical Science, University of Catania, Viale A. Doria 6, 95125, Catania, Italy.
Daniele CondorelliDepartment of Biomedical and Biotechnological Sciences, Section of Medical Biochemistry, University of Catania, Via Santa Sofia 89, 95123, Catania, Italy.
Vincenza BarresiDepartment of Biomedical and Biotechnological Sciences, Section of Medical Biochemistry, University of Catania, Via Santa Sofia 89, 95123, Catania, Italy.
Graziella VecchioDepartment of Chemical Science, University of Catania, Viale A. Doria 6, 95125, Catania, Italy.ORCID 0000-0001-8305-081X

Funding

NextGenerationEU-MUR PNRR 2022JXSA9CNextGenerationEU-MUR PNRR INF-ACTNextGenerationEU-MUR PNRR PE00000007
6 · The paper itself

Abstract

Cyclodextrin dimers have been investigated as potential nanocapsules of biomolecules. The presence of two cavities can improve the stability of inclusion complexes, working as a hydrophilic sandwich of poorly water-soluble species. Here, we designed new β- and γ-cyclodextrin dimers functionalized with biotin as a targeting unit and tested the new bioconjugates as doxorubicin delivery systems in cancer cells. Biotin can recognize the Sodium-dependent Multivitamin Transporter (SMVT) receptor, encoded by the Solute Carrier Family 5 Member 6 (SLC5A6) gene and improve the uptake of drugs. We evaluated the expression of the SLC5A6 transcript in human cell lines to select the best cell model (MCF-7) for the in vitro studies. Furthermore, in the cell lines, we investigated the transcript levels of genes correlated to biotin cell availability, Holocarboxylase Synthetase (or HCS encoded by HLCS gene) and Biotinidase (encoded by BTD gene) enzymes. Moreover, the expression of ATP Binding Cassette Subfamily G Member 2 transporter (encoded by ABCG2 gene), which may play a role in doxorubicin resistance, has been investigated. The antiproliferative activity of the doxorubicin complexes with the dimers has been determined to study the effect of the biotin moiety on the cytotoxicity in MCF-7 cancer cells.

Indexed as

BiotinCell ProliferationCyclodextrinsDoxorubicinDrug Screening Assays, AntitumorNanocapsulesAntibiotics, AntineoplasticBreast NeoplasmsCell SurvivalDimerizationDose-Response Relationship, DrugDrug CarriersDrug Delivery SystemsHumansMCF-7 CellsMolecular StructureAntibiotics, AntineoplasticBiotinCyclodextrinsDoxorubicinDrug CarriersNanocapsulesBiotinCyclodextrinDoxorubicinDrug delivery

Identifiers

PMID39246269
PMCPMC11648824

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.