ArticleAmerican journal of physiology. Cell physiology2024
Bacterial lipopolysaccharide inhibits free thiamin uptake along the intestinal tract via interference with membrane expression of thiamin transporters 1 and 2.
Article in American journal of physiology. Cell physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
6 authors.
Selvaraj AnthonymuthuDepartments of Physiology/Biophysics, School of Medicine, University of California, Irvine, California, United States.ORCID 0000-0001-7316-1436
Subrata SabuiDepartments of Physiology/Biophysics, School of Medicine, University of California, Irvine, California, United States.
Kameron Isaiah ManzonDepartments of Physiology/Biophysics, School of Medicine, University of California, Irvine, California, United States.
Alaullah SheikhDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States.ORCID 0000-0002-2972-6978
James M FleckensteinDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States.
Hamid M SaidDepartments of Physiology/Biophysics, School of Medicine, University of California, Irvine, California, United States.ORCID 0000-0003-1016-8547
Funding
Washington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Jeffrey Wade Brown · 2000 to 2026
$30.8M
Novel Antigen Identification for an Enterotoxigenic E. coli VaccineR01AI089894 · NIAID · WASHINGTON UNIVERSITY · PI Zachary T. Berndsen, James Michael Fleckenstein · 2010 to 2026
$7.4M
Physiology/Pathophysiology of Vitamin B1 Transport in Pancreatic Acinar CellsR01AA018071 · NIAAA · UNIVERSITY OF CALIFORNIA-IRVINE · PI SAID, HAMID M · 2009 to 2023
$6.3M
Vitamin B1 (thiamin) transport in Alzheimer’s Disease: Role of microRNAs in regulating level of expression of its transporters (SLC19A2 & SLC19A3) in human brain cells and effect of hypoxiaR01DK056061 · NIDDK · UNIVERSITY OF CALIFORNIA-IRVINE · PI SAID, HAMID M · 1999 to 2024
$5.0M
Mechanism/Regulation of Intestinal Thiamin UptakeR37DK056061 · NIDDK · UNIVERSITY OF CALIFORNIA-IRVINE · PI SAID, HAMID M · 2009 to 2018
$3.6M
Molecular Pathogenesis of enterotoxigenic E. coli associated enteropathyR01AI170949 · NIAID · WASHINGTON UNIVERSITY · PI James Michael Fleckenstein · 2023 to 2026
$2.4M
DNA METHYLATION: PATTERNS AND POSSIBLE REGULATORY ROLESR01AG001807 · NIA · FLORIDA STATE UNIVERSITY · PI TAYLOR, J HERBERT · 1985 to 1985
–
Molecular Pathogenesis of Enterotoxigenic Escherichia coli InfectionsI01BX001469 · VA · ST. LOUIS VA MEDICAL CENTER · PI FLECKENSTEIN, JAMES MICHAEL · 2013 to 2017
–
BLRD Research Career Scientist Award ApplicationIK6BX006189 · VA · VETERANS HEALTH ADMINISTRATION · PI HAMID M SAID · 2023 to 2026
–
Physiological and Pathological Aspects of Intestinal Vitamin B2 AbsorptionI01BX001142 · VA · VETERANS HEALTH ADMINISTRATION · PI HAMID M SAID · 2011 to 2026
–
BLRD VA I01 BX001142BLRD VA I01 BX001469BLRD VA IK6 BX006189HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI089894HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI170949HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK56061HHS | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA) AA018071HHS | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA) AA-018071S1NIAAA NIH HHS R01 AA018071NIAID NIH HHS R01 AI089894NIAID NIH HHS R01 AI170949NIDDK NIH HHS P30 DK052574NIDDK NIH HHS R01 DK056061NIDDK NIH HHS R37 DK056061U.S. Department of Veterans Affairs (VA) 5I01BX001469U.S. Department of Veterans Affairs (VA) I01BX001142U.S. Department of Veterans Affairs (VA) IK6BX006189
6 · The paper itself
Abstract
This study examined the effect of exposure of small and large intestinal epithelial cells to the bacterial lipopolysaccharide (LPS) on uptake of free form of vitamin B1, i.e., thiamin. The intestinal tract encounters two sources of thiamin: diet and the gut microbiota. Absorption of thiamin in both the small and large intestine occurs via a carrier-mediated process that involves thiamin transporters 1 and 2 (THTR-1 and -2). Complementary in vitro (human duodenal epithelial HuTu-80 cells and human colonic epithelial NCM460 cells), in vivo (mice), and ex vivo (human primary differentiated enteroid and colonoid monolayers) models were used. The results showed that exposure to LPS causes a significant inhibition in carrier-mediated [
Indexed as
Intestinal MucosaLipopolysaccharidesThiamineAnimalsCell LineCell MembraneCyclic AMP-Dependent Protein KinasesEpithelial CellsHumansMaleMembrane Transport ProteinsMiceMice, Inbred C57BLCyclic AMP-Dependent Protein KinasesLipopolysaccharidesMembrane Transport ProteinsSLC19A2 protein, humanSLC19A3 protein, humanThiaminebacterial lipopolysaccharidehuman enteroid/colonoid monolayersintestinal/colonic uptakethiaminTHTR-1 and -2
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Bacterial lipopolysaccharide inhibits free thiamin uptake along the intestinal tract via interference with membrane expression of thiamin transporters 1 and 2. · full record | OpenQuestion