Evidence map›Paper›PMID 39246120›Full record

ArticleEuropean journal of immunology2024

MicroRNA-146a deficiency enhances host protection against murine cytomegalovirus.

Pamela Wong, Jeffrey W Leong, Hyogon Sohn, Lily Chang, Catherine R Keppel, Carly C Neal, Celia C Cubitt, Tony Yao, Molly P Keppel, Jennifer Tran and 13 more

Abstract read
In one paragraph

Article in European journal of immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Pamela WongDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Jeffrey W LeongDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Hyogon SohnDivison of Rheumatology/Immunology, Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA.
Lily ChangDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Catherine R KeppelDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Carly C NealDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Celia C CubittDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0003-0037-9324
Tony YaoDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Molly P KeppelDivison of Rheumatology/Immunology, Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA.
Jennifer TranDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Allison BurdiDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Kimberly HwangDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Leslie A FogelDivison of Rheumatology/Immunology, Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA.
Timothy SchappeDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Lynne MarsalaDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Melissa M Berrien-ElliottDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Julia A WagnerDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Stephanie E SchneiderDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Ryan P SullivanDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Jeanette T PingelDivison of Rheumatology/Immunology, Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA.
Megan A CooperDivison of Rheumatology/Immunology, Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA.
Anthony R FrenchDivison of Rheumatology/Immunology, Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA.
Todd A FehnigerDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0M
Targeting the Bone Marrow Microenvironment In Acute Lymphocytic LeukemiaP50CA171963 · NCI · WASHINGTON UNIVERSITY · PI Daniel C Link · 2013 to 2026
$31.6M
PRE-AND POSTGRADUATE TRAINING IN MOLECULAR HEMATOLOGYT32HL007088 · NHLBI · WASHINGTON UNIVERSITY · PI Grant Anthony Challen, Stephen Oh · 1985 to 2026
$14.1M
Washington University Paul Calabresi K12 Career Development Award for Clinical OncologyK12CA167540 · NCI · WASHINGTON UNIVERSITY · PI John F. Dipersio, Ramaswamy Govindan · 2012 to 2026
$11.7M
TRANSLATING NK CELL BIOLOGY INTO CLINICAL CANCER IMMUNOTHERAPYR01CA205239 · NCI · WASHINGTON UNIVERSITY · PI FEHNIGER, TODD A · 2017 to 2020
$2.4M
METABOLIC REGULATION OF NATURAL KILLER CELL ACTIVATIONR01AI127752 · NIAID · WASHINGTON UNIVERSITY · PI COOPER, MEGAN ANNE · 2017 to 2021
$1.9M
INNATE IMMUNE RECEPTOR ANTAGONISM BY ORTHOPOXVIRUS PROTEINSR01AI073552 · NIAID · WASHINGTON UNIVERSITY · PI FRENCH, ANTHONY R · 2008 to 2011
$1.5M
MICRORNA REGULATION OF NK CELL DEVELOPMENT AND FUNCTIONR01AI102924 · NIAID · WASHINGTON UNIVERSITY · PI FEHNIGER, TODD A · 2013 to 2016
$1.5M
Mechanism of CD8 regulation of natural killer cell biologyF30AI161318 · NIAID · WASHINGTON UNIVERSITY · PI CUBITT, CELIA CLAIRE · 2021 to 2024
$152k
Elucidating the role of EOMES in Memory-Like NK cell DifferentiationF31GM146361 · NIGMS · WASHINGTON UNIVERSITY · PI TRAN, JENNIFER · 2022 to 2024
$90k
Howard Hughes Medical InstituteJamie Erin Follicular Lymphoma Research FundLeukemia and Lymphoma SocietyLymphoma Research FoundationNCI NIH HHS K12 CA167540NCI NIH HHS P30 CA091842NCI NIH HHS P50 CA171963NCI NIH HHS R01 CA205239NHLBI NIH HHS T32 HL007088NIAID NIH HHS F30 AI161318NIAID NIH HHS R01 AI073552NIAID NIH HHS R01 AI102924NIAID NIH HHS R01 AI127752NIGMS NIH HHS F31 GM146361NIH HHS F30 AI161318NIH HHS F31 GM146361NIH HHS K12 5K12CA167540NIH HHS P50CA171963NIH HHS R01 AI073552NIH HHS R01AI102924NIH HHS R01AI127752NIH HHS R01 CA205239NIH HHS T32 HL007088NIH/NCI P30CA091842Paula and Rodger Riney FoundationV Foundation for Cancer Research
6 · The paper itself

Abstract

Natural killer (NK) cells are innate lymphoid cells that protect a host from viral infections and malignancies. MicroRNA-146a (miR-146a) is an important regulator of immune function that is highly expressed in NK cells and is further upregulated during murine cytomegalovirus (MCMV) infection. Here we utilized mice with a global targeted deletion of miR-146a to understand its impact on the innate immune responses to MCMV infection. MiR-146a

Indexed as

Herpesviridae InfectionsKiller Cells, NaturalMice, KnockoutMicroRNAsMuromegalovirusAnimalsImmunity, InnateMiceMice, Inbred C57BLSTAT1 Transcription FactorT-LymphocytesMicroRNAsMirn146 microRNA, mouseStat1 protein, mouseSTAT1 Transcription FactorInnate immunityNK cells

Identifiers

PMID39246120
PMCPMC12356503

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.