Trial reportJournal of the International Society of Sports Nutrition2024
Caffeine, but not paracetamol (acetaminophen), enhances muscular endurance, strength, and power.
Trial report in Journal of the International Society of Sports Nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Effects of acute caffeine ingestion combined with post-activation potentiation enhancement on the anaerobic capacity of male collegiate basketball players.Journal of the International Society of Sports Nutrition · 2026Trial
- Trial
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- Individual responses to encapsulated caffeine and caffeine chewing gum on strength and power in strength-trained males.Journal of the International Society of Sports Nutrition · 2025Trial
- Caffeine's influence on vertical jump height: a real-life collegiate student-athlete approach.Journal of the International Society of Sports Nutrition · 2025Trial
- Trial
- Caffeine Enhances Some Aspects of Physical Performance in Well-Trained Hammer and Discus Throwers.Nutrients · 2024Trial
- The intervention effect of caffeine oral tablets on mental fatigue induced by nap deprivation: based on assessments of heart rate variability, cognitive performance and subjective fatigue-a pilot study.Frontiers in public health · 2026Article
- Acute effects of caffeine and paracetamol on velocity and power in resistance exercise.Frontiers in physiology · 2025Article
- Exploring the impact of BMI and physical activity on caffeine use disorder and nutritional attitudes among adults in Türkiye.Frontiers in nutrition · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCaffeine is one of the most popular ergogenic aids consumed by athletes. Caffeine's ergogenic effect has been generally explained by its ability to bind to adenosine receptors, thus modulating pain and reducing perceived exertion. Another pharmacological agent that may improve performance due to its analgesic proprieties is paracetamol. This study aimed to explore the effects of caffeine, paracetamol, and caffeine + paracetamol consumption on muscular endurance, strength, power, anaerobic endurance, and jumping performance.
methodsIn this randomized, crossover, double-blind study, 29 resistance-trained participants (11 men and 18 women) ingested either a placebo, caffeine (3 mg/kg), paracetamol (1500 mg) or caffeine + paracetamol 45 min before the testing sessions. The testing sessions included performing the bench press exercise with 75% of one-repetition maximum to momentary muscular failure, isokinetic knee extension and flexion at angular velocities of 60°/sec and 180°/sec, Wingate, and countermovement jump (CMJ) tests.
resultsCompared to placebo, isolated caffeine ingestion increased the number of repetitions performed in the bench press (
conclusionThis study provided novel evidence into the effectiveness of caffeine, paracetamol, and their combination on exercise performance. We found improvements in muscular endurance, strength, or power only when caffeine was consumed in isolation, or in combination with paracetamol. Isolated paracetamol consumption did not improve performance for any of the analyzed outcomes, thus calling into question its ergogenic potential.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.