Evidence map›Paper›PMID 39245696›Full record

ArticleAnnals of biomedical engineering2025

Predicting Steady-State Metabolic Power in Cerebral Palsy, Stroke, and the Elderly During Walking With and Without Assistive Devices.

Karl Harshe, Benjamin C Conner, Zachary F Lerner

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Article in Annals of biomedical engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Karl HarsheDepartment of Mechanical Engineering, Northern Arizona University, Flagstaff, AZ, 86001, USA.
Benjamin C ConnerCollege of Medicine - Phoenix, University of Arizona, Phoenix, AZ, USA.
Zachary F LernerDepartment of Mechanical Engineering, Northern Arizona University, Flagstaff, AZ, 86001, USA. Zachary.Lerner@nau.edu.ORCID http://orcid.org/0000-0002-7359-436X

Funding

Investigation of the neuromuscular response and training effects of wearable adaptive resistance in children with cerebral palsyF30HD103318 · NICHD · UNIVERSITY OF ARIZONA · PI CONNER, BENJAMIN CHARLES · 2021 to 2024
$183k
Division of Chemical, Bioengineering, Environmental, and Transport Systems 2045966National Center for Medical Rehabilitation Research 1R01HD107277National Center for Medical Rehabilitation Research R15HD099664National Institute of Child Health and Human Development F30HD103318
6 · The paper itself

Abstract

purposeIndividuals with walking impairment, such as those with cerebral palsy, often face challenges in leading physically active lives due to the high energy cost of movement. Assistive devices like powered exoskeletons aim to alleviate this burden and improve mobility. Traditionally, optimizing the effectiveness of such devices has relied on time-consuming laboratory-based measurements of energy expenditure, which may not be feasible for some patient populations. To address this, our study aimed to enhance the state-of-the-art predictive model for estimating steady-state metabolic rate from 2-min walking trials to include individuals with and without walking disabilities and for a variety of terrains and wearable device conditions.

methodsUsing over 200 walking trials collected from eight prior exoskeleton-related studies, we trained a simple linear machine learning model to predict metabolic power at steady state based on condition-specific factors, such as whether the trial was conducted on a treadmill (level or incline) or outdoors, as well as demographic information, such as the participant's weight or presence of walking impairment, and 2 minutes of metabolic data.

resultsWe demonstrated the ability to predict steady-state metabolic rate to within an accuracy of 4.71 ± 2.7% on average across all walking conditions and patient populations, including with assistive devices and on different terrains.

conclusionThis work seeks to unlock the use of in-the-loop optimization of wearable assistive devices in individuals with limited walking capacity. A freely available MATLAB application allows other researchers to easily apply our model.

Indexed as

Cerebral PalsyEnergy MetabolismExoskeleton DeviceSelf-Help DevicesStrokeWalkingAdultAgedFemaleHumansMachine LearningMaleMiddle AgedWearable Electronic DevicesCerebral palsyExoskeletonMachine learningMetabolic steady state

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.