Evidence map›Paper›PMID 39245691›Full record

SynthesisProgress in orthodontics2024

Relationship between craniofacial skeletal patterns and anatomic characteristics of masticatory muscles: a systematic review and meta-analysis.

David Togninalli, Gregory S Antonarakis, Alexandra K Papadopoulou

Erratum issued Registry-linked trialAbstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Progress in orthodontics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT06870084 (The Relationship Between Masseter Muscle Thickness and Different Craniofacial Skeletal Patterns), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06870084 completednot on this map

The Relationship Between Masseter Muscle Thickness and Different Craniofacial Skeletal Patterns

Typeobservational_patient_registrySponsorKutahya Health Sciences UniversityRan2024 to 2025Enrolled101ConditionsMasseter, Ultrasonography, Malocclusions, CephalometryArmsUltrasonography, Lateral cephalometric radiography, Facial photograph, Weigth and Heigth, Electronic caliper
3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Dentofacial effects of lingual versus labial fixed appliances in adults treated with four-premolar extractions and skeletal anchorage-supported mechanics : A retrospective comparative cephalometric study.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Observational
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

David TogninalliDivision of Orthodontics, University Clinics of Dental Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Gregory S AntonarakisDivision of Orthodontics, University Clinics of Dental Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Alexandra K PapadopoulouDivision of Orthodontics, University Clinics of Dental Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland. Alexandra.Papadopoulou@unige.ch.ORCID http://orcid.org/0000-0001-5981-0479

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe anatomic characteristics of the masticatory muscles differ across craniofacial skeletal patterns.

objectiveTo identify differences in the anatomic characteristics of masticatory muscles across different sagittal and vertical craniofacial skeletal patterns. ELIGIBILITY CRITERIA: Studies measuring the thickness, width, cross-sectional area (CSA), volume and orientation of masticatory muscles in healthy patients of different sagittal (Class I, Class II, and Class III) and/or vertical (normodivergent, hypodivergent, and hyperdivergent) patterns. INFORMATION SOURCES: Unrestricted literature searches in 8 electronic databases/registers until December 2023. RISK OF BIAS AND SYNTHESIS OF

resultsStudy selection, data extraction, and risk of bias assessment with a customised tool were performed independently in duplicate. Random-effects meta-analysis and assessment of the certainty of clinical recommendations with the GRADE approach were conducted.

results34 studies (37 publications) were selected with a total of 2047 participants and data from 16 studies were pulled in the meta-analysis. Masseter muscle thickness in relaxation was significantly greater by 1.14 mm (95% CI 0.74-1.53 mm) in hypodivergent compared to normodivergent patients while it was significantly decreased in hyperdivergent patients by - 1.14 mm (95% CI - 1.56 to - 0.73 mm) and - 2.28 mm (95% CI - 2.71 to - 1.85 mm) compared to normodivergent and hypodivergent patients respectively. Similar significant differences were seen between these groups in masseter muscle thickness during contraction as well as masseter muscle CSA and volume. Meta-analyses could not be performed for sagittal categorizations due to insufficient number of studies.

conclusionsConsiderable differences in masseter muscle thickness, CSA and volume were found across vertical skeletal configurations being significantly reduced in hyperdivergent patients; however, results should be interpreted with caution due to the high risk of bias of the included studies. These variations in the anatomic characteristics of masticatory muscles among different craniofacial patterns could be part of the orthodontic diagnosis and treatment planning process. REGISTRATION: PROSPERO CRD42022371187 .

Indexed as

Masticatory MusclesCephalometryFacial BonesHumansMalocclusionMasseter MuscleCraniofacial patternMasseterMasticatory musclesMeta-analysisSkeletal patternSystematic review

Identifiers

PMID39245691
PMCPMC11381490

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.