Evidence map›Paper›PMID 39245658›Full record

ArticlePediatric nephrology (Berlin, Germany)2025

The impact of climate variation on the spread of Shiga toxin-producing E. coli.

Branavan Nagarajan, Ana Cabrera, Michael R Miller, Amrit Kirpalani

Abstract read
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Article in Pediatric nephrology (Berlin, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Branavan NagarajanDepartment of Paediatrics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Ana CabreraDepartment of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Michael R MillerDepartment of Paediatrics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Amrit KirpalaniDepartment of Paediatrics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. amrit.kirpalani@lhsc.on.ca.ORCID http://orcid.org/0000-0001-7567-9052

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundShiga toxin-producing Escherichia coli (STEC) is influenced by seasonality, but there is limited understanding of how specific climatic variables contribute to disease spread. This information aids in understanding disease transmission dynamics and could potentially inform public health modeling.

methodsThis retrospective cohort study analyzed public health data from Ontario, Canada, between 2012 and 2021, along with historical climate data from Environment Canada. We employed Seasonal Autoregressive Integrated Moving Average (S-ARIMA) models to assess how temperature and precipitation impact the incidence of STEC infections, measured per 10,000,000 population.

resultsThe study included 1658 confirmed STEC cases. A significant correlation was found between STEC incidence and climatic variables. Each degree Celsius increase in maximum temperature was associated with a rise of 3 STEC cases per 10,000,000 population (Centers for Disease Control and Prevention (2024)). Additionally, each millimeter of increased precipitation correlated with an increase of 1.1 cases per 10,000,000 population.

conclusionsThe findings demonstrate a significant impact of temperature and precipitation on STEC transmission, highlighting the importance of integrating meteorological data into public health surveillance. This integration may help inform public health responses and support healthcare systems in planning for future outbreaks. Further studies are needed to refine predictive models and develop effective early warning systems for clinical settings.

Indexed as

Escherichia coli InfectionsSeasonsShiga-Toxigenic Escherichia coliAdolescentAdultChildChild, PreschoolClimateClimate ChangeFemaleHumansIncidenceInfantInfant, NewbornMaleMiddle AgedHemolytic uremic syndromeS-ARIMAShiga toxin–producing Escherichia coli (STEC)

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.