Evidence map›Paper›PMID 39245250›Full record

ReviewHeart rhythm2025

Prediction of sudden cardiac death using artificial intelligence: Current status and future directions.

Maarten Z H Kolk, Samuel Ruipérez-Campillo, Arthur A M Wilde, Reinoud E Knops, Sanjiv M Narayan, Fleur V Y Tjong

Abstract readReview
In one paragraph

Review in Heart rhythm, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  16. Molecular Mechanisms of Cardiac Adaptation After Device Deployment.Journal of cardiovascular development and disease · 2025
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  18. Article
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  20. Left Ventricular Non-Compaction: Evolving Concepts.Journal of clinical medicine · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Maarten Z H KolkDepartment of Clinical and Experimental Cardiology, Amsterdam UMC Location University of Amsterdam, Heart Center, Amsterdam, The Netherlands; Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, Amsterdam UMC location AMC, Amsterdam, The Netherlands.
Samuel Ruipérez-CampilloDepartment of Computer Science, ETH Zurich, Zurich, Switzerland.
Arthur A M WildeDepartment of Clinical and Experimental Cardiology, Amsterdam UMC Location University of Amsterdam, Heart Center, Amsterdam, The Netherlands; Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, Amsterdam UMC location AMC, Amsterdam, The Netherlands.
Reinoud E KnopsDepartment of Clinical and Experimental Cardiology, Amsterdam UMC Location University of Amsterdam, Heart Center, Amsterdam, The Netherlands; Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, Amsterdam UMC location AMC, Amsterdam, The Netherlands.
Sanjiv M NarayanDepartment of Medicine and Cardiovascular Institute, Stanford University, Stanford, California.
Fleur V Y TjongDepartment of Clinical and Experimental Cardiology, Amsterdam UMC Location University of Amsterdam, Heart Center, Amsterdam, The Netherlands; Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, Amsterdam UMC location AMC, Amsterdam, The Netherlands. Electronic address: f.v.tjong@amsterdamumc.nl.

Funding

Machine Learning for Ventricular ArrhythmiasR01HL162260 · NHLBI · STANFORD UNIVERSITY · PI Sanjiv M Narayan · 2023 to 2026
$2.5M
NHLBI NIH HHS R01 HL162260
6 · The paper itself

Abstract

Sudden cardiac death (SCD) remains a pressing health issue, affecting hundreds of thousands each year globally. The heterogeneity among people who suffer a SCD, ranging from individuals with severe heart failure to seemingly healthy individuals, poses a significant challenge for effective risk assessment. Conventional risk stratification, which primarily relies on left ventricular ejection fraction, has resulted in only modest efficacy of implantable cardioverter-defibrillators for SCD prevention. In response, artificial intelligence (AI) holds promise for personalized SCD risk prediction and tailoring preventive strategies to the unique profiles of individual patients. Machine and deep learning algorithms have the capability to learn intricate nonlinear patterns between complex data and defined end points, and leverage these to identify subtle indicators and predictors of SCD that may not be apparent through traditional statistical analysis. However, despite the potential of AI to improve SCD risk stratification, there are important limitations that need to be addressed. We aim to provide an overview of the current state-of-the-art of AI prediction models for SCD, highlight the opportunities for these models in clinical practice, and identify the key challenges hindering widespread adoption.

Indexed as

Artificial IntelligenceDeath, Sudden, CardiacGlobal HealthHumansRisk AssessmentRisk FactorsArtificial intelligenceDeep learningImplantable cardioverter-defibrillatorMachine learningSudden cardiac deathVentricular arrhythmia

Identifiers

PMID39245250
PMCPMC12057726

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.