Evidence map›Paper›PMID 39245243›Full record

ArticleEnvironmental toxicology and pharmacology2024

In vitro endocrine and cardiometabolic toxicity associated with artificial turf materials.

Kyle R Siegel, Brooklynn R Murray, Jeff Gearhart, Christopher D Kassotis

Abstract read
In one paragraph

Article in Environmental toxicology and pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kyle R SiegelDepartment of Pharmacology and Institute of Environmental Health Sciences, Wayne State University, Detroit, MI 48202, United States.
Brooklynn R MurrayDepartment of Pharmacology and Institute of Environmental Health Sciences, Wayne State University, Detroit, MI 48202, United States.
Jeff GearhartResearch Director, Ecology Center, Ann Arbor, MI 48104, United States.
Christopher D KassotisDepartment of Pharmacology and Institute of Environmental Health Sciences, Wayne State University, Detroit, MI 48202, United States. Electronic address: christopher.kassotis@wayne.edu.

Funding

Pilot Project ProgramP30ES020957 · NIEHS · WAYNE STATE UNIVERSITY · PI RUDEN, DOUGLAS M · 2014 to 2021
$10.1M
Translational Research Support CoreP30ES036084 · NIEHS · WAYNE STATE UNIVERSITY · PI Melissa A Runge-Morris · 2024 to 2026
$5.2M
Translation CoreP2CES033423 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CHAU TRINH-SHEVRIN, Lorna Thorpe · 2022 to 2026
$5.1M
NIEHS NIH HHS P2C ES033423NIEHS NIH HHS P30 ES020957NIEHS NIH HHS P30 ES036084
6 · The paper itself

Abstract

Artificial turf, a consumer product growing in usage in the United States, contains diverse chemicals, some of which are endocrine disruptive. Endocrine effects from turf material extracts have been primarily limited to one component, crumb rubber, of these multi-material products. We present in vitro bioactivities from non-weathered and weathered turf sample extracts, including multiple turf components. All weathered samples were collected from real-world turf fields. Non-weathered versus weathered differentially affected the androgen (AR), estrogen (ER), glucocorticoid (GR), and thyroid receptors (TR) in reporter bioassays. While weathered extracts more efficaciously activated peroxisome proliferator activated receptor γ (PPARγ), this did not translate to greater in vitro adipogenic potential. All turf extracts activated the aryl hydrocarbon receptor (AhR). High AhR-efficacy extracts induced modest rat cardiomyoblast toxicity in an AhR-dependent manner. Our data demonstrate potential endocrine and cardiometabolic effects from artificial turf material extracts, warranting further investigation into potential exposures and human health effects.

Indexed as

Endocrine DisruptorsReceptors, Aryl HydrocarbonAnimalsCell LineHumansMyocytes, CardiacRatsEndocrine DisruptorsReceptors, Aryl HydrocarbonAdipogenesisCardiotoxicityEndocrine disruptionLeachateNuclear receptorSynthetic turf

Identifiers

PMID39245243
PMCPMC11499011

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.