Evidence map›Paper›PMID 39245153›Full record

ArticleCardiovascular pathology : the official journal of the Society for Cardiovascular Pathology

Serotonin transporter deficiency in mice results in an increased susceptibility to HTR2B-dependent pro-fibrotic mechanisms in the cardiac valves and left ventricular myocardium.

Estibaliz Castillero, Chiara Camillo, Dov Levine, Alex M D'Angelo, Yaagnik Kosuri, Juan B Grau, Robert J Levy, Giovanni Ferrari

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Estibaliz CastilleroDepartment of Surgery, Columbia University; New York, NY 10032, USA; Department of Physiology, University of the Basque Country (UPV/EHU), Leioa, Spain.
Chiara CamilloDepartment of Surgery, Columbia University; New York, NY 10032, USA.
Dov LevineDepartment of Surgery, Columbia University; New York, NY 10032, USA.
Alex M D'AngeloDepartment of Surgery, Columbia University; New York, NY 10032, USA.
Yaagnik KosuriDepartment of Surgery, Columbia University; New York, NY 10032, USA.
Juan B GrauValley Hospital Heart Institute, Ridgewood, NJ 07450, USA.
Robert J LevyThe Topolewski Pediatric Heart Valve Center, and the Division of Cardiology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Giovanni FerrariDepartment of Surgery, Columbia University; New York, NY 10032, USA; Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA. Electronic address: gf2375@cumc.columbia.edu.

Funding

Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3M
POSTDOCTORAL TRAINING IN ARTERIOSCLEROSIS RESEARCHT32HL007343 · NHLBI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI HENRY N GINSBERG, Muredach P Reilly · 1985 to 2026
$12.7M
Supplement to Serotonin Signaling in Mitral Valve Homeostasis, Maintenance and RestorationR01HL131872 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI Giovanni Ferrari, Robert J Levy · 2016 to 2026
$7.7M
NCI NIH HHS P30 CA013696NHLBI NIH HHS R01 HL131872NHLBI NIH HHS T32 HL007343
6 · The paper itself

Abstract

Increased serotonin (5HT) concentration and signaling, can lead to pathological remodeling of the cardiac valves. We previously showed that a reduction of the 5HT transporter (SERT) expression in the mitral valve (MV) contributes to the progression of degenerative MV regurgitation (MR). We sought to investigate the myocardial and valvular phenotype of SERT

Indexed as

Collagen Type I, alpha 1 ChainDisease Models, AnimalFibrosisMice, KnockoutReceptor, Serotonin, 5-HT2BSerotonin Plasma Membrane Transport ProteinsVentricular RemodelingAnimalsCells, CulturedCollagen Type IFemaleFibroblastsHeart ValvesHumansMaleMiceCol1a1 protein, mouseCollagen Type ICollagen Type I, alpha 1 ChainReceptor, Serotonin, 5-HT2BSerotonin Plasma Membrane Transport ProteinsSlc6a4 protein, mouseTgfb1 protein, mouseTransforming Growth Factor beta15HTCardiac fibrosisMitral valveValvulopathy

Identifiers

PMID39245153
PMCPMC11585425

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.