Evidence map›Paper›PMID 39245031›Full record

Trial reportAIDS care2024

Development of a home-based pre-exposure prophylaxis care delivery system for long-acting injectable cabotegravir: a formative exploration of patient preferences.

Janelly Gonzalez, Paulina A Rebolledo, Aaron J Siegler, Wenting Huang, Kenneth H Mayer, Valeria D Cantos

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in AIDS care, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Janelly GonzalezHubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Paulina A RebolledoHubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Aaron J SieglerDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Wenting HuangDepartment of Behavioral, Social, and Health Education Science, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Kenneth H MayerDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Valeria D CantosDivision of Infectious Disease, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.

Funding

Making it last: A randomized, controlled trial of a home care system to promote persistence in PrEP careR01MH114692 · NIMH · EMORY UNIVERSITY · PI MAYER, KENNETH H, SIEGLER, AARON JULIUS · 2017 to 2021
$5.8M
Establishing PREMISE: A PrEP Epidemiology, Modeling, and Surveillance SystemR01AI181799 · NIAID · EMORY UNIVERSITY · PI Aaron Julius Siegler, Patrick Sean Sullivan · 2024 to 2026
$3.0M
NIAID NIH HHS R01 AI181799NIMH NIH HHS R01 MH114692
6 · The paper itself

Abstract

Cabotegravir (CAB-LA), the only Food and Drug Administration-approved injectable pre-exposure prophylaxis (PrEP), is effective and may address PrEP uptake disparities among Black and Latino sexual and gender minority (SGM) men. Uptake of CAB-LA may require developing innovative non-clinic-based care delivery strategies in home-based settings. We explored SGM men's opinions on a future home-based CAB-LA PrEP care service to guide the adaptation of PrEP@Home, an existing home-based PrEP system for oral PrEP. Through 14 in-depth interviews with current or former SGM male participants in the PrEP@Home study, we explored the acceptability of a home-based injectable PrEP system and examined visit and communication-related preferences. All participants considered home-based CAB-LA care to be acceptable and 8/14 would utilize the system if available. Convenience and comfort with using a home-based system impacted the overall acceptance of the approach. Factors influencing acceptability included clinical teams' affiliation with healthcare systems, a credentialed two-person team, and staff identity verification methods. Logistical preferences included communicating pre-visit patient instructions, allowing flexible scheduling hours, and the use of text, phone calls, or mobile app communication methods based on urgency. Conclusively, a home-based CAB-LA PrEP delivery system was acceptable among the interviewed SGM men, guiding its development and future implementation.

Indexed as

Anti-HIV AgentsHIV InfectionsPatient PreferencePre-Exposure ProphylaxisPyridonesAdultDiketopiperazinesHome Care ServicesHumansInjectionsInterviews as TopicMaleMiddle AgedPatient Acceptance of Health CareSexual and Gender MinoritiesAnti-HIV AgentscabotegravirDiketopiperazinesPyridonesCAB-LA PrEPHome-based carepatient preferencesSDG 10: Reduced inequalitiesSDG 3: Good health and well-being

Identifiers

PMID39245031
PMCPMC12128582

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.