Evidence map›Paper›PMID 39244732›Full record

ArticleInternational journal of cancer2025

Uncovering possible silent acquired long QT syndrome using exercise stress testing in long-term pediatric acute lymphoblastic leukemia survivors.

Audrey Harvey, Maxime Caru, Cecilia Gonzalez Corcia, Émilie Bertrand, Vincent Gagné, Smita Dandekar, Maja Krajinovic, Hugo Gravel, Caroline Laverdière, Marie-Josée Raboisson and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Audrey HarveyFaculty of Medicine, School of Kinesiology and Physical Activity Sciences, University of Montreal, Montreal, Quebec, Canada.
Maxime CaruDepartment of Pediatrics, Division of Hematology and Oncology, Pennsylvania State Health Children's Hospital, Hershey, Pennsylvania, USA.ORCID 0000-0003-2904-9185
Cecilia Gonzalez CorciaSainte-Justine University Health Center, Research Center, Montreal, Canada.
Émilie BertrandFaculty of Medicine, School of Kinesiology and Physical Activity Sciences, University of Montreal, Montreal, Quebec, Canada.
Vincent GagnéSainte-Justine University Health Center, Research Center, Montreal, Canada.
Smita DandekarDepartment of Pediatrics, Division of Hematology and Oncology, Pennsylvania State Health Children's Hospital, Hershey, Pennsylvania, USA.
Maja KrajinovicSainte-Justine University Health Center, Research Center, Montreal, Canada.
Hugo GravelFaculty of Medicine, School of Kinesiology and Physical Activity Sciences, University of Montreal, Montreal, Quebec, Canada.
Caroline LaverdièreSainte-Justine University Health Center, Research Center, Montreal, Canada.
Marie-Josée RaboissonSainte-Justine University Health Center, Research Center, Montreal, Canada.
Gregor AndelfingerSainte-Justine University Health Center, Research Center, Montreal, Canada.
Vincent JacquemetDepartment of Pharmacology and Physiology, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada.
Daniel SinnettSainte-Justine University Health Center, Research Center, Montreal, Canada.
Daniel CurnierFaculty of Medicine, School of Kinesiology and Physical Activity Sciences, University of Montreal, Montreal, Quebec, Canada.

Funding

C17 Children's Cancer and Blood DisordersCanada First Research Excellence Fund through the TransMedTech InstituteCanadian Cancer Society Research InstituteCancer Research SocietyCIHRCole Foundation, Fonds de Recherche du Québec - Santé (FRQS)Garron Family Cancer CentreOntario Institute for Cancer ResearchPediatric Oncology Group of OntarioSainte-Justine University Hospital Center Foundation and Foundation of Stars
6 · The paper itself

Abstract

An example of chemotherapy-induced cardiotoxicity in cancer survivors is acquired long QT syndrome (aLQTS), which may cause serious yet preventable life-threatening consequences. Our objective was to identify and characterize childhood acute lymphoblastic leukemia (ALL) survivors with possible aLQTS using maximal exercise testing. In this cross-sectional study with exploratory analysis, a total of 250 childhood ALL survivors were evaluated for abnormal QT interval prolongation using the McMaster cycle exercise test. A total of 198 survivors (102 males; 96 females), having reached their

Indexed as

Cancer SurvivorsExercise TestLong QT SyndromePrecursor Cell Lymphoblastic Leukemia-LymphomaAdolescentAdultCardiotoxicityChildChild, PreschoolCross-Sectional StudiesElectrocardiographyFemaleHeart RateHumansMaleYoung Adultchildhood cancer survivorsexerciseLQTSQT interval

Identifiers

PMID39244732
PMCPMC11578077

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.