ArticleInternational urology and nephrology2025
U-shaped association between hemoglobin levels and albuminuria in US adults: a cross-sectional study.
Article in International urology and nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Anemia in diabetes mellitus: Pathogenetic aspects and the value of early erythropoietin therapy.Metabolism open · 2025Review
- Relationship between hemoglobin and red blood cell distribution width ratio and albuminuria in the United States adults aged 20 years and above: a cross-sectional analysis.Frontiers in nutrition · 2025Article
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Authors and funding
2 authors.
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Abstract
purposeThis study aimed to explore the correlation between hemoglobin levels and albuminuria in US adults.
methodsThis cross-sectional investigation analyzed the National Health and Nutrition Examination Survey (NHANES) information from 2011 to 2020. Data on hemoglobin, albuminuria, and other variables were collected from all participants. The logistic-regression analyses and smoothed curves were used to substantiate the research objectives.
resultsThe average age of the 8,868 participants was 49.5 ± 17.3 years, and 49.3% were men. The prevalence of albuminuria was 12.1%. After adjusting for potential variables in the logistic-regression analysis models, hemoglobin (per 1 g/dL increase) was inversely associated with the presence of albuminuria (odds ratio [OR], 0.92; 95% confidence interval [95%CI], 0.87-0.97). Compared with participants in quartile 3 (Q3, 14.1-15.0 g/dL) for hemoglobin levels, those in the lowest quartile 1 (Q1, 6.1-13.0 g/dL) and highest quartile 4 (Q4, 15.1-19.6 g/dL) had adjusted ORs for albuminuria of 1.48 (95% CI, 1.19-1.85) and 1.11 (95% CI, 0.9-1.38), respectively. Our observations indicated a U-shaped association between hemoglobin levels and albuminuria, with a point of inflection at approximately 15.5 g/dL. The effect sizes and CIs below and above this point were 0.853 (95% CI, 0.798-0.912) and 1.377 (95% CI, 1.055-1.797), respectively.
conclusionThis study indicates that the presence of albuminuria is linked to both low and high hemoglobin levels in US adults. The management of hemoglobin may benefit kidney health.
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