Evidence map›Paper›PMID 39244636›Full record

ArticleCommunications biology2024

PHD2 safeguards modest mesendoderm development.

Meng Li, Huaizhang Jin, Yun Zhao, Guoping Zhu, Yu Liu, Hongan Long, Xiaopeng Shen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Meng LiCollege of Life Sciences, Anhui Normal University, Wuhu, Anhui, China.ORCID 0000-0001-6490-7136
Huaizhang JinCollege of Life Sciences, Anhui Normal University, Wuhu, Anhui, China.
Yun ZhaoCollege of Life Sciences, Anhui Normal University, Wuhu, Anhui, China.
Guoping ZhuCollege of Life Sciences, Anhui Normal University, Wuhu, Anhui, China.
Yu LiuDepartment of Biology and Biochemistry, University of Houston, Houston, TX, USA.ORCID 0000-0002-1282-4897
Hongan LongInstitute of Evolution and Marine Biodiversity, KLMME, Ocean University of China, Qingdao, Shandong, China.
Xiaopeng ShenCollege of Life Sciences, Anhui Normal University, Wuhu, Anhui, China. shenxiaopeng_cn@ahnu.edu.cn.ORCID 0000-0002-6116-635X

Funding

Anhui Science and Technology Department (Department of Science and Technology of Anhui Province) 2208085MH209, 1808085QH234National Natural Science Foundation of China (National Science Foundation of China) 31701289
6 · The paper itself

Abstract

PHD2 is essential in modulating HIF-1α levels upon oxygen fluctuations. Hypoxia, a hallmark of uterus, and HIF-1α have recently emerged as opposing regulators of mesendoderm specification, suggesting a role for PHD2 therein. We found that PHD2 expression initially covered the epiblast and gradually receded from the primitive streak, which was identical to hypoxia and exclusive to HIF-1α. The investigations performed in mESCs, embryoids, and mouse embryos together demonstrated that PHD2 negatively regulated mesendoderm specification. Single-cell RNA sequencing revealed that PHD2 governed the transition from epiblast to mesendoderm. The downstream effect of PHD2 relied on the HIF-1α regulated Wnt/β-catenin pathway, while it was regulated upstream by miR-429. In summary, our research highlights PHD2's essential role in mesendoderm specification and its interactions with hypoxia and HIF-1α.

Indexed as

Hypoxia-Inducible Factor 1, alpha SubunitHypoxia-Inducible Factor-Proline DioxygenasesAnimalsEndodermGene Expression Regulation, DevelopmentalMesodermMiceMicroRNAsWnt Signaling PathwayEgln1 protein, mouseHif1a protein, mouseHypoxia-Inducible Factor 1, alpha SubunitHypoxia-Inducible Factor-Proline DioxygenasesMicroRNAs

Identifiers

PMID39244636
PMCPMC11380689

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.