ArticleNature communications2024
Smoking and alcohol by HPV status in head and neck cancer: a Mendelian randomization study.
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Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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26citing papers in PubMed, 2 pooled it
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A genome-wide association study of buccal mucosa cancer in India and multi-ancestry meta-analysis discovers risk loci and gene-environment interactions.EBioMedicine · 2025Pooled it
- The Prognostic Role of miR-375 in Head and Neck Squamous Cell Carcinoma: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis.International journal of molecular sciences · 2025Pooled it
- Tobacco and Alcohol Exposure as Confounders in Assessing HPV-Related Cancer Trends After Male Vaccination.Reviews in medical virology · 2026Article
- Diagnostic work-up strategies impact on head and neck Squamous Cell Carcinoma (SCC) of unknown primary survival: a national multicentric retrospective analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Article
- Association of alcohol consumption with oral high-risk human papillomavirus infection: a cross-sectional study within the multinational HPV infection in men (HIM) cohort.Lancet regional health. Americas · 2026Article
- Low HPV16 E6 Seroprevalence in HNSCC: A Prospective Study in Brazil.Journal of clinical medicine · 2026Article
- Multiple programmed cell death patterns predict the prognosis and therapeutic sensitivity in head and neck squamous cell carcinoma.Discover oncology · 2026Article
- Therapeutic Landscape of HPV-Associated Cancers: From Mechanisms and Conventional Approaches to Future Innovations.Cancers · 2026Review
- GPR65 as a Laryngeal Cancer Risk Gene Identified through Single-Cell Transcriptomics, Mendelian Randomization Analysis, and Experimental Validation.Anti-cancer agents in medicinal chemistry · 2026Article
- Association of Smoking and Alcohol Consumption with Female Reproductive Diseases: A Mendelian Randomization Study on the Mediating Role of Circulating Metabolites.International journal of women's health · 2026Article
- CCDC86 modulates immune cell infiltration and disease progression in head and neck squamous cell carcinoma.Discover oncology · 2025Article
- Impact of smoking and alcohol consumption on telomere length: A univariable and multivariable Mendelian randomization study.Medicine · 2025Article
- Review
- Mendelian randomization analysis of gut microbiota-immune cell interactions in malignant neoplasm of nasopharynx.AMB Express · 2025Article
- Article
- The Association Between Alcohol Consumption and Anal Human Papillomavirus in the HPV Infection in Men Study.medRxiv : the preprint server for health sciences · 2025Article
- Capacity building of community health officers for optimizing the screening and early diagnosis of oral cancer in Jodhpur, Rajasthan, India.Scientific reports · 2025Article
- VOYAGER: an international consortium investigating the role of human papilloma virus and genetics in oral and oropharyngeal cancer risk and survival.medRxiv : the preprint server for health sciences · 2025Article
- Porcupine expression promotes the progression of oral carcinogenesis.Neoplasia (New York, N.Y.) · 2025Article
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Authors and funding
41 authors.
Abhinav Thakral *Department of Biostatistics, Princess Margaret Cancer Centre-University Health Network, University of Toronto, Toronto, Ontario, Canada.
John Jw Lee *Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, Ontario, Canada. Jongwook.lee@utoronto.ca.ORCID 0000-0002-3364-9960
Tianzhichao HouDepartment of Biostatistics, Princess Margaret Cancer Centre-University Health Network, University of Toronto, Toronto, Ontario, Canada.
Katrina HuenikenDepartment of Biostatistics, Princess Margaret Cancer Centre-University Health Network, University of Toronto, Toronto, Ontario, Canada.
Tom DuddingMRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS8 1TL, UK.ORCID 0000-0003-3756-040X
Mark GormleyMRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS8 1TL, UK.ORCID 0000-0001-5733-6304
Shama ViraniGenomic Epidemiology Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France.ORCID 0000-0002-1163-432X
Andrew OlshanDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA.
Brenda DiergaardeDepartment of Human Genetics, School of Public Health, University of Pittsburgh, and UPMC Hillman Cancer Center, Pittsburgh, PA, 15260, USA.
Andrew R NessUniversity Hospitals Bristol and Weston NHS Foundation Trust National Institute for Health Research Bristol Biomedical Research Centre, University of Bristol, Bristol, BS1 3NU, UK.
Tim WaterboerInfections and Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-0616-6963
Karl Smith-ByrneGenomic Epidemiology Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France.ORCID 0000-0002-1932-7463
Paul BrennanGenomic Epidemiology Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France.
D Neil HayesDivision of Medical Oncology and Center for Cancer Research, University of Tennessee Health Science Center, Memphis, TN, USA.ORCID 0000-0001-6203-7771
Eleanor SandersonMRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS8 1TL, UK.ORCID 0000-0001-5188-5775
M Catherine BrownPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.ORCID 0000-0003-0184-7732
Sophie HuangPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Scott V BratmanPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Anna SpreaficoPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.ORCID 0000-0002-3034-3042
John De AlmeidaDepartment of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, Ontario, Canada.
Joel C DaviesDepartment of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, Ontario, Canada.
Laura BierutDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-9952-4810
Gary J MacfarlaneEpidemiology Group, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK.
Pagona LagiouDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian, University of Athens, Goudi, Greece.
Areti LagiouDepartment of Public and Community Health, School of Public Health, University of West Attica, Athens, Greece.
Jerry PoleselUnit of Cancer Epidemiology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.ORCID 0000-0001-9381-1520
Antonio AgudoCancer Epidemiology Research Programme, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Madrid, Spain.
Laia AlemanyCancer Epidemiology Research Programme, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Madrid, Spain.
Wolfgang AhrensDepartment of Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany; Department of Mathematics and Computer Science, University of Bremen, Bremen, Germany.ORCID 0000-0003-3777-570X
Claire M HealyDepartment of Oral and Maxillofacial Surgery, Oral Medicine and Oral Pathology, Dublin Dental University Hospital, Trinity College Dublin, Dublin, Ireland.
David I ConwaySchool of Medicine, Dentistry, and Nursing, University of Glasgow, Glasgow, UK.
Mari NygardDepartment of Research, Cancer Registry of Norway, Norwegian Institute of Public Health, Oslo, Norway.
Cristina CanovaUniversity of Padua, Padova, Italy.
Ivana HolcatovaInstitute of Hygiene & Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.ORCID 0000-0002-1366-0337
Lorenzo RichiardiDepartment of Medical Sciences, University of Turin and CPO-Piemonte, Turin, Italy.ORCID 0000-0003-0316-9402
Ariana ZnaorCancer Surveillance Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France.
David P GoldsteinDepartment of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0001-9390-7928
Rayjean J HungProsserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Canada.
Wei XuDepartment of Biostatistics, Princess Margaret Cancer Centre-University Health Network, University of Toronto, Toronto, Ontario, Canada.
Geoffrey LiuInfections and Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. Geoffrey.Liu@uhn.ca.
Osvaldo Espin-GarciaDepartment of Biostatistics, Princess Margaret Cancer Centre-University Health Network, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0003-2052-2626
Funding
VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTOPHER J. BAKKENIST · 1988 to 2026
$158.0MWILD TYPE P53-BASED ADJUVANT IMMUNOTHERAPY FOR SCCHNP50CA097190 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Heath Devin Skinner · 2004 to 2026
$49.6MUNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Hazel B Nichols · 2001 to 2026
$36.3MGene Environment Interaction in Head and Neck CancerR01CA090731 · NCI · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI OLSHAN, ANDREW · 2001 to 2005
$4.6MThe role of germline and somatic DNA mutations in oral and oropharyngeal cancersR01DE025712 · NIDCR · INTERNATIONAL AGENCY FOR RES ON CANCER · PI BRENNAN, PAUL JOSEPH, DIERGAARDE, BRENDA B. · 2017 to 2021
$3.3MCancer Research UK C18281/A19169NCI NIH HHS P30 CA047904NCI NIH HHS P50 CA097190NCI NIH HHS R01 CA090731NIDCR NIH HHS R01 DE025712NIEHS NIH HHS P30 ES010126World Health Organization 001
Abstract
HPV-positive and HPV-negative head and neck squamous cell carcinoma (HNSCC) are recognized as distinct entities. There remains uncertainty surrounding the causal effects of smoking and alcohol on the development of these two cancer types. Here we perform multivariable Mendelian randomization (MR) to evaluate the causal effects of smoking and alcohol on the risk of HPV-positive and HPV-negative HNSCC in 3431 cases and 3469 controls. Lifetime smoking exposure, as measured by the Comprehensive Smoking Index (CSI), is associated with increased risk of both HPV-negative HNSCC (OR = 3.03, 95%CI:1.75-5.24, P = 7.00E-05) and HPV-positive HNSCC (OR = 2.73, 95%CI:1.39-5.36, P = 0.003). Drinks Per Week is also linked with increased risk of both HPV-negative HNSCC (OR = 7.72, 95%CI:3.63-16.4, P = 1.00E-07) and HPV-positive HNSCC (OR = 2.66, 95%CI:1.06-6.68, P = 0.038). Smoking and alcohol independently increase the risk of both HPV-positive and HPV-negative HNSCC. These findings have important implications for understanding the modifying risk factors between HNSCC subtypes.
Indexed as
Alcohol DrinkingHead and Neck NeoplasmsMendelian Randomization AnalysisPapillomavirus InfectionsSmokingSquamous Cell Carcinoma of Head and NeckCase-Control StudiesFemaleHumansMaleMiddle AgedPapillomaviridaePolymorphism, Single NucleotideRisk Factors
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