ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2024
Association between FTO polymorphism and COVID-19 mortality among older adults: A population-based cohort study.
Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Serum extracellular vesicle RNA profiles in long COVID: insights from exercise-induced gene modulation.Scientific reports · 2026Trial
- N6-methyladenosine modification in the context of viral infection: from molecular mechanism to therapeutic potential.Virus research · 2026Review
- Association of the FTO gene polymorphism with the features of the clinical course of tuberculosis infection.BMC infectious diseases · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectivesCOVID-19 caused a global pandemic with millions of deaths. Fat mass and obesity-associated gene (FTO) (alias m
methodsWe tested a population-based cohort of 5233 subjects (aged 63-87 years in 2020) where 70 persons died from COVID-19 and 394 from other causes during the pandemic period.
resultsThe frequency of GG homozygotes was higher among those who died from COVID-19 (34%) than among survivors (19%) or deaths from other causes (20%), P <0.005. After multiple adjustments, GG homozygotes had a higher risk of death from COVID-19 with odds ratio = 2.01 (95% confidence interval; 1.19-3.41, P <0.01) compared with carriers of at least one T allele. The FTO polymorphism was not associated with mortality from other causes.
conclusionsOur results suggest that FTO variability is a significant predictor of COVID-19-associated mortality in Caucasians.
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