Evidence map›Paper›PMID 39244090›Full record

ArticleMucosal immunology2024

Dietary fiber promotes antigen presentation on intestinal epithelial cells and development of small intestinal CD4

Naomi Rodriguez-Marino, Charlotte J Royer, Dormarie E Rivera-Rodriguez, Emma Seto, Isabelle Gracien, Rheinallt M Jones, Christopher D Scharer, Adam D Gracz, Luisa Cervantes-Barragan

Abstract read
In one paragraph

Article in Mucosal immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Naomi Rodriguez-MarinoDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, United States.
Charlotte J RoyerDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, United States; Current affiliation. Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, United States.
Dormarie E Rivera-RodriguezDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, United States; Emory Vaccine Center, , Emory University School of Medicine, Atlanta, GA, United States; Division of Infectious Diseases, Department of Medicine, , Emory University School of Medicine, Atlanta, GA, United States.
Emma SetoDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, United States.
Isabelle GracienDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, United States.
Rheinallt M JonesDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, , Emory University School of Medicine, Atlanta, GA, United States.
Christopher D ScharerDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, United States; Emory Vaccine Center, , Emory University School of Medicine, Atlanta, GA, United States.
Adam D GraczDivision of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, United States.
Luisa Cervantes-BarraganDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, United States. Electronic address: lcervantes@emory.edu.

Funding

Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
Antimicrobial Resistance and Therapeutic Discovery Training ProgramT32AI106699 · NIAID · EMORY UNIVERSITY · PI Graeme L Conn, Joanna B Goldberg · 2014 to 2026
$2.7M
Regulation of intestinal stem cell state by ID3R35GM142503 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Adam David Gracz · 2021 to 2026
$2.5M
Role of dietary fiber-microbiota Interactions in the development and function of small intestinal T cellsR01DK129950 · NIDDK · EMORY UNIVERSITY · PI CERVANTES BARRAGAN, LUISA · 2021 to 2025
$2.4M
NCATS NIH HHS UL1 TR002378NIAID NIH HHS T32 AI106699NIDDK NIH HHS R01 DK129950NIGMS NIH HHS R35 GM142503
6 · The paper itself

Abstract

The impact of dietary fiber on intestinal T cell development is poorly understood. Here we show that a low fiber diet reduces MHC-II antigen presentation by small intestinal epithelial cells (IECs) and consequently impairs development of CD4

Indexed as

Antigen PresentationDietary FiberIntestinal MucosaIntestine, SmallIntraepithelial LymphocytesAnimalsBifidobacteriumCD8 AntigensCell DifferentiationEpithelial CellsGastrointestinal MicrobiomeHistocompatibility Antigens Class IIInterferon-gammaMiceMice, Inbred C57BLCD8 AntigensDietary FiberHistocompatibility Antigens Class IIInterferon-gammaAntigen presentationDietary fiberDP IELILC1Interferon-γIntestinal epithelial cellsIntraepithelial T cellsMicrobiotaSegmented filamentous bacteria

Identifiers

PMID39244090
PMCPMC11742265

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.