Evidence map›Paper›PMID 39243979›Full record

Observational studyJournal of substance use and addiction treatment2024

Buprenorphine discontinuation in telehealth-only treatment for opioid use disorder: A longitudinal cohort analysis.

Brian Chan, Ryan Cook, Ximena Levander, Katharina Wiest, Kim Hoffman, Kellie Pertl, Ritwika Petluri, Dennis McCarty, P Todd Korthuis, Stephen A Martin

Registry-linked trialAbstract readObservational Study
In one paragraph

Observational study in Journal of substance use and addiction treatment, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03224858 (Does a Clinic Based Complex Care Coordination Intervention Improve Patient Quality Outcomes in an Underserved Clinic Population? The Streamlined, Unified, Meaningfully Managed Interdisciplinary Team), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03224858 nacompletednot on this map

Does a Clinic Based Complex Care Coordination Intervention Improve Patient Quality Outcomes in an Underserved Clinic Population? The Streamlined, Unified, Meaningfully Managed Interdisciplinary Team (SUMMIT) Ambulatory ICU Study

TypeinterventionalSponsorOregon Health and Science UniversityRan2016 to 2021Enrolled200ConditionsHealth Services, Comorbidity, Primary Health CareArmsSUMMIT intervention, Enhanced usual care
3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Brian ChanDivision of General Internal Medicine and Geriatrics, Section of Addiction Medicine, Oregon Health & Science University, Portland, OR, United States of America; Central City Concern, Portland, OR, United States of America. Electronic address: chanbri@ohsu.edu.
Ryan CookDivision of General Internal Medicine and Geriatrics, Section of Addiction Medicine, Oregon Health & Science University, Portland, OR, United States of America.
Ximena LevanderDivision of General Internal Medicine and Geriatrics, Section of Addiction Medicine, Oregon Health & Science University, Portland, OR, United States of America.
Katharina WiestBoulder Care, Portland, OR, United States of America.
Kim HoffmanDivision of General Internal Medicine and Geriatrics, Section of Addiction Medicine, Oregon Health & Science University, Portland, OR, United States of America.
Kellie PertlBoulder Care, Portland, OR, United States of America.
Ritwika PetluriBoulder Care, Portland, OR, United States of America.
Dennis McCartySchool of Public Health, Oregon Health & Science University and Portland State University, Portland, OR, United States of America.
P Todd KorthuisDivision of General Internal Medicine and Geriatrics, Section of Addiction Medicine, Oregon Health & Science University, Portland, OR, United States of America; School of Public Health, Oregon Health & Science University and Portland State University, Portland, OR, United States of America.
Stephen A MartinBoulder Care, Portland, OR, United States of America; Department of Family Medicine and Community Health, UMass Chan Medical School, Worcester, MA, United States of America.

Funding

Western States Node of the National Drug Abuse Treatment Clinical Trials Network (TMS for CUD) UG1DA015815 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Keith N. Humphreys, Philip Todd Korthuis · 2015 to 2026
$24.6M
Evaluating the Usability, Efficacy and Commercial Utility of a Digital Platform to Deliver Comprehensive Treatment for Opioid Use DisorderR44DA050354 · NIDA · BOULDER CARE, INC. · PI PAPES, STEPHANIE · 2019 to 2022
$1.7M
Identifying High Utilizing Patients with Opioid Use Disorder to Engage in Primary CareK23DA053390 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Brian Chan · 2022 to 2026
$886k
Transporting treatment effects from clinical trials to real-world populations with co-occurring opioid and stimulant use disordersK01DA055130 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI COOK, RYAN · 2022 to 2025
$714k
AHRQ HHS K12 HS026370NIDA NIH HHS K01 DA055130NIDA NIH HHS K23 DA053390NIDA NIH HHS R44 DA050354NIDA NIH HHS UG1 DA015815
6 · The paper itself

Abstract

introductionAt the beginning of the COVID-19 pandemic, federal agencies permitted telehealth initiation of buprenorphine treatment for opioid use disorder (OUD) without in-person assessment. It remains unclear how telehealth-only buprenorphine treatment impacts time to discontinuation and patient reported treatment outcomes.

methodsA longitudinal observational cohort study conducted September 2021 through March, 2023 enrolled participants with OUD initiating buprenorphine (≤ 45 days) with internet and phone access in Oregon and Washington. The intervention was a fully telehealth-only (THO) app versus treatment as usual (TAU) in office-based settings with some telehealth. We assessed self-reported buprenorphine discontinuation at 4-,12-, and 24-weeks. Generalized estimating equations (GEE) calculated unadjusted and adjusted relative risk ratios (RR) for discontinuation averaged over the study period. Secondary outcomes included change in the Brief Addiction Monitor (BAM) and the visual analogue craving scale. Generalized linear models estimated average within-group and between-group differences over time.

resultsParticipants (n = 103 THO; n = 56 TAU) had a mean age of 37 years (SD = 9.8 years) and included 52 % women, 83 % with Medicaid insurance, 80 % identified as White, 65 % unemployed/student, and 19 % unhoused. There were differences in gender (THO = 54 % women vs. TAU = 44 %, p = .04), unemployed status (60 % vs 75 %, p = .02), and stable housing (84 % vs 73 %, p = .02). Rates of buprenorphine discontinuation were low in the THO (4 %) and TAU (13 %) groups across 24 weeks. In the adjusted analysis, the risk of discontinuation was 61 % lower in the THO group (aRR = 0.39, 95 % CI [0.17, 0.89], p = .026). Decreases occurred over time on the harms subscale of the BAM (within-group difference - 0.85, p = .0004 [THO], and - 0.68, p = .04 [TAU]) and cravings (within-group difference - 13.47, p = .0001 [THO] vs -7.65, p = .01 [TAU]).

conclusionsA telehealth-only platform reduced the risk of buprenorphine discontinuation compared to office-based TAU. In-person evaluation to receive buprenorphine may not be necessary for treatment-seeking patients. CLINICAL TRIALS IDENTIFIER: NCT03224858.

Indexed as

BuprenorphineOpiate Substitution TreatmentOpioid-Related DisordersTelemedicineAdultCohort StudiesCOVID-19FemaleHumansLongitudinal StudiesMaleMiddle AgedOregonWashingtonBuprenorphineMedications for opioid use disorderOpioid use disorderTelemedicine

Identifiers

PMID39243979
PMCPMC12002408

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.