Evidence map›Paper›PMID 39243075›Full record

ArticleBMC public health2024

Effectiveness of malaria chemoprevention in the first two years of life in Cameroon and Côte d'Ivoire compared to standard of care: study protocol for a population-based prospective cohort impact evaluation study.

Gillian Stresman, Sham Lal, Jane Bruce, Akindeh Nji, Assi Serge-Brice, Jonna Mosoff, Alba McGirr, Georgia Gore-Langton, Michaela McGuire, James Sinsai and 10 more

2 registry-linked trialsAbstract readClinical Trial Protocol
In one paragraph

Article in BMC public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05856357 active not recruitingnot on this map

Impact Evaluation of Intermittent Preventive Treatment of Malaria in Infants Plus (IPTi+) in Côte D'Ivoire: the Plus Project

TypeobservationalSponsorLondon School of Hygiene and Tropical MedicineRan2023 to 2025Enrolled1,568ConditionsMalaria, AnemiaArmsSulfadoxine pyrimethamine
NCT05889052 active not recruitingnot on this map

Impact Evaluation of Intermittent Preventive Treatment of Malaria in Infants Plus (IPTi+) in Cameroon: the Plus Project

TypeobservationalSponsorLondon School of Hygiene and Tropical MedicineRan2023 to 2025Enrolled2,080ConditionsAnemia, MalariaArmsSulfadoxine pyrimethamine
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Genetic Diversity ofTropical medicine and infectious disease · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Gillian Stresman *Department of Epidemiology, College of Public Health, University of South Florida, 13201 Bruce B Downs Blvd, Tampa, FL, USA. gstresman@usf.edu.
Sham Lal *Department of Disease Control, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London, UK. Sham.Lal@lshtm.ac.uk.
Jane BruceDepartment of Disease Control, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London, UK.
Akindeh NjiFobang Institute for Innovation in Science and Technology, 14 Missionary Road, Simbok, Yaounde, Cameroon.
Assi Serge-BriceNational Institute of Public Health, B.P. V47, Abidjan, Côte d'Ivoire.
Jonna MosoffDepartment of Disease Control, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London, UK.
Alba McGirrDepartment of Disease Control, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London, UK.
Georgia Gore-LangtonDepartment of Disease Control, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London, UK.
Michaela McGuireDepartment of Epidemiology, College of Public Health, University of South Florida, 13201 Bruce B Downs Blvd, Tampa, FL, USA.
James SinsaiFobang Institute for Innovation in Science and Technology, 14 Missionary Road, Simbok, Yaounde, Cameroon.
Albertine LeleFobang Institute for Innovation in Science and Technology, 14 Missionary Road, Simbok, Yaounde, Cameroon.
Mercy Tah-MonundeFobang Institute for Innovation in Science and Technology, 14 Missionary Road, Simbok, Yaounde, Cameroon.
Zah-Bi KouadioNational Institute of Public Health, B.P. V47, Abidjan, Côte d'Ivoire.
Mian AnatoleNational Institute of Public Health, B.P. V47, Abidjan, Côte d'Ivoire.
Abibatou Konate-ToureNational Institute of Public Health, B.P. V47, Abidjan, Côte d'Ivoire.
Sian Elisabeth ClarkeDepartment of Disease Control, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London, UK.
Roland GoslingDepartment of Disease Control, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London, UK.
Wilfred Fon Mbacham *Fobang Institute for Innovation in Science and Technology, 14 Missionary Road, Simbok, Yaounde, Cameroon.
William Yavo *National Institute of Public Health, B.P. V47, Abidjan, Côte d'Ivoire.
R Matthew Chico *Department of Disease Control, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London, UK. Matthew.Chico@lshtm.ac.uk.

Funding

Unitaid 101150IC
6 · The paper itself

Abstract

backgroundPerennial malaria chemoprevention (PMC) is a chemoprevention strategy endorsed by the World Health Organization (WHO) and is increasingly being adopted by National Malaria Programmes. PMC aims to reduce morbidity and mortality caused by malaria and anaemia in in young children through provision of antimalarial drugs at routine contact points with the local health system. This study aims to evaluate the impact of the programmatically-implemented country-tailored PMC programmes targeting children up to two years of age using sulfadoxine-pyrimethamine (SP) on the incidence of malaria and anaemia in children in Cameroon and Côte d'Ivoire.

methodsWe will assess the impact of PMC using passive and active monitoring of a prospective observational cohort of children up to 36 months of age at recruitment in selected study sites in Cameroon and Côte d'Ivoire. The primary and secondary outcomes include malaria, anaemia and malnutrition incidence. We will also conduct a time-series analysis of passively detected malaria and anaemia cases comparing the periods before and after PMC introduction. This study is powered to detect a 30% and 40% reduction of malaria incidence compared to the standard of care in Cameroon and Côte d'Ivoire, respectively. DISCUSSION: This multi-country study aims to provide evidence of the effectiveness of PMC targeting children in the first two years of life on malaria and anaemia and will provide important information to inform optimal operationalization and evaluation of this strategy.

trial registrationCameroon - NCT05889052; Côte d'Ivoire - NCT05856357.

Indexed as

AnemiaAntimalarialsChemopreventionMalariaPyrimethamineSulfadoxineCameroonChild, PreschoolCote d'IvoireDrug CombinationsFemaleHumansIncidenceInfantMaleProspective StudiesAntimalarialsDrug Combinationsfanasil, pyrimethamine drug combinationPyrimethamineSulfadoxineBurden reductionCohort studEarly childhoodIntermittent preventive treatmentPerennial malaria chemoprevention

Identifiers

PMID39243075
PMCPMC11378462

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.