Evidence map›Paper›PMID 39243033›Full record

ArticleBMC nephrology2024

Tubulointerstitial nephropathy is the predominant finding in men in a review of more than 3000 renal biopsies over a 10-year period from Sri Lanka.

Jennifer Pett, Christine Linhart, Nicholas Osborne, Stephen Morrell, Mohammed Fahim, John Knight, Shakila Premaranthne, A W M Wazil, Neelakanthi Ratnatunga, Sulcochana Wijethunga and 4 more

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Article in BMC nephrology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. CKDPediatric nephrology (Berlin, Germany) · 2026
    Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Jennifer PettSchool of Population Health, University of New South Wales, UNSW, Sydney, Australia.
Christine LinhartSchool of Population Health, University of New South Wales, UNSW, Sydney, Australia. c.linhart@unsw.edu.au.
Nicholas OsborneSchool of Population Health, University of New South Wales, UNSW, Sydney, Australia. n.osborne@uq.edu.au.
Stephen MorrellSchool of Population Health, University of New South Wales, UNSW, Sydney, Australia.
Mohammed FahimSouth Asian Clinical Toxicology Research Collaboration, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka.
John KnightSchool of Population Health, University of New South Wales, UNSW, Sydney, Australia.
Shakila PremaranthneDepartment of Microbiology, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka.
A W M WazilNephrology and Kidney Transplant Unit, National Hospital, Kandy, Sri Lanka.
Neelakanthi RatnatungaDepartment of Pathology, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka.
Sulcochana WijethungaDepartment of Pathology, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka.
Shenal ThalgahagodaDepartment of Paediatrics, Faculty of Medicine, University of Peradeniya Teaching Hospital, Peradeniya, Sri Lanka.
Zoltan EndreSchool of Clinical Medicine, Faculty of Medicine and Health, UNSW, Sydney, Australia.
Richard TaylorSchool of Population Health, University of New South Wales, UNSW, Sydney, Australia.
Nishantha NanayakkaraNephrology and Kidney Transplant Unit, National Hospital, Kandy, Sri Lanka.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic kidney disease (CKD) is a significant clinical challenge in Sri Lanka. The present study presents histopathological diagnoses from native renal biopsies in Kandy District, 2011-2020.

methodsReports of 5,014 renal biopsies principally performed at Kandy Teaching Hospital over 2011-2020 were reviewed. After exclusions for post-kidney transplant biopsies (1,572) and those without evident pathology (347), 3,095 biopsies were included. The predominant histopathological entities were grouped and categorised according to diagnosis and stratified by age and sex.

resultsThe main histopathological entities (all biopsies) were tubulointerstitial nephropathy (TIN) 25% (n = 760), glomerulonephritis (GN) 15% (467), lupus nephropathy 14% (429), focal segmental glomerular sclerosis (FSGS) 10% (297), and IgA nephropathy (IgAN) 8% (242). For adult women ≥ 15 years, the main histopathological entities were lupus nephropathy 24% (325), TIN 17% (228), and GN 16% (217). For adult men ≥ 15 years, the main histopathological entities were TIN 34% (449), GN 14% (180), and IgAN 10% (125). The proportion of TIN in the present study was higher than international studies of a similar size.

conclusionThis is the largest study of renal biopsies reported from Sri Lanka to date. TIN was the most common diagnosis in adults ≥ 15 years at 25%. Notable sex differences showed TIN was the most common histopathology in men (34%) but not in women (17%). No previously published similar study of this size has found TIN as the predominant diagnosis amongst renal biopsies in men. Further research is required into the possible causes of these observations in Sri Lanka. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

KidneyNephritis, InterstitialAdolescentAdultAgedBiopsyChildChild, PreschoolFemaleGlomerulonephritisGlomerulonephritis, IGAGlomerulosclerosis, Focal SegmentalHumansLupus NephritisMaleMiddle AgedChronic kidney disease of unknown aetiologyCKDCKDuRenal biopsySri LankaTubulointerstitial nephropathy

Identifiers

PMID39243033
PMCPMC11378423

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.