Evidence map›Paper›PMID 39242985›Full record

ArticleBMC immunology2024

Revised version with tracked changes oral Magnesium reduces levels of pathogenic autoantibodies and skin disease in murine lupus.

Alberto Verlato, Teresina Laragione, Sofia Bin, Randie H Kim, Fadi Salem, Percio S Gulko, Paolo Cravedi

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Alberto VerlatoPrecision Immunology Institute, Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, Box 1243, New York, NY, 10029, USA.
Teresina LaragioneDivision of Rheumatology, Department of Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, Box 1243, New York, NY, 10029, USA.
Sofia BinPrecision Immunology Institute, Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, Box 1243, New York, NY, 10029, USA.
Randie H KimDermatopathology Section, The Kimberley and Eric J. Waldman Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Fadi SalemDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL, USA.
Percio S GulkoDivision of Rheumatology, Department of Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, Box 1243, New York, NY, 10029, USA. percio.gulko@mssm.edu.
Paolo CravediPrecision Immunology Institute, Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, Box 1243, New York, NY, 10029, USA. paolo.cravedi@mssm.edu.

Funding

Magnesium and Arthritis PathogenesisR01AR073165 · NIAMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GULKO, PERCIO S · 2019 to 2023
$1.8M
NIAMS NIH HHS R01 AR073165NIH HHS R01AR073165
6 · The paper itself

Abstract

backgroundSystemic Lupus Erythematosus (SLE) has a strong genetic susceptibility, but little is known about the impact of diet on disease severity. The Western diet is typically deficient in magnesium (Mg), and given the immunomodulatory effects of Mg, we hypothesized that the low Mg intake increases disease risk and that increasing Mg intake would reduce severity of murine lupus. Here, we placed 12-week old MRL/lpr female lupus mice on a normal (Mg500) or a high (Mg2800) Mg diet for 9 weeks. Urine and blood were collected during the study for quantification of urinary albumin, BUN, anti-dsDNA antibodies, and immune phenotyping.

resultsMRL/lpr lupus mice on high Mg2800 diet had significantly fewer skin lesions and less severe skin histology score, and reduced levels of pathogenic anti-dsDNA antibodies, compared with the Mg500 group (143.8±75.0 vs. 47.4±36.2 × 10

conclusionIn conclusion, oral supplementation of Mg has a protective effect in a murine lupus model and may represent an inexpensive and safe adjuvant in the treatment of SLsE.

Indexed as

Antibodies, AntinuclearLupus Erythematosus, SystemicMagnesiumT-Lymphocytes, RegulatoryAdministration, OralAnimalsAutoantibodiesDisease Models, AnimalFemaleMiceMice, Inbred MRL lprSkinSkin DiseasesAntibodies, Antinuclearanti-dsDNA autoantibodyAutoantibodiesMagnesium

Identifiers

PMID39242985
PMCPMC11378425

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.