ArticleNPJ Parkinson's disease2024
Neural correlates of bradykinesia in Parkinson's disease: a kinematic and functional MRI study.
Article in NPJ Parkinson's disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The trial behind it
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Who cites it
16 citing papers in PubMed.
- Bilateral intermittent theta burst stimulation over the primary motor cortex improves motor and affective symptoms via thalamic network reintegration in mid-stage Parkinson's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Trial
- Auditory cueing modulates motor performance and brain activity in early Parkinson's disease-a kinematic and fMRI study.NPJ Parkinson's disease · 2026Article
- Dynamic neural states underpin motor symptom severity in Parkinson's disease: a longitudinal analysis of chronic cortico-subthalamic nucleus recordings.EBioMedicine · 2026Article
- Distinct finger-tapping feature in progressive supranuclear palsy correlates with motor function and brain atrophy.NPJ Parkinson's disease · 2026Article
- Automated video analysis for early detection of bradykinesia in Parkinson's disease.Journal of neuroengineering and rehabilitation · 2026Article
- Magnetoencephalography-based prediction of longitudinal symptom progression in Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Analyzing the 'Bradykinesia Complex' in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- A Network Centered on the Visual-Motor Cortex Is Critically Involved in Postural Abnormality in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Volumetric signatures of basal ganglia-thalamo-cortical and cerebello-thalamo-cortical networks in Parkinson's disease and its motor subtypes.Frontiers in aging neuroscience · 2026Article
- Construct validity, intrarater and interrater reliability of the Italian version of the systematic screening of handwriting difficulties (SOS) test in people with Parkinson's disease.Journal of neurology · 2025Article
- Automated detection of Parkinson's disease using improved linknet-ghostnet model based on handwriting images.Scientific reports · 2025Article
- Validation of the Comprehensive Augmented Reality Testing Platform to Quantify Parkinson's Disease Fine Motor Performance.Journal of clinical medicine · 2025Article
- Handwriting, touchscreen dexterity and bradykinesia measures in Parkinson's disease: a feature selection study.Journal of neurology · 2025Article
- Cerebellar Contributions to Hypokinetic Symptoms in an Acute Lesion Parkinsonism Model.Neurology international · 2025Article
- Neural control meets biomechanics in the motor assessment of neurological disorders: a narrative review.Frontiers in neural circuits · 2025Review
- Individualized cortico-basal ganglia network effective connectivity predicts outcomes of STN-DBS in patients with Parkinson's disease.Frontiers in neuroscience · 2025Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Bradykinesia is defined as a "complex" of motor alterations including decreased movement amplitude and/or speed and tendency to reduce them with movement repetition (sequence effect). This study aimed at investigating the neural and kinematic correlates of bradykinesia during hand-tapping in people with Parkinson's disease (pwPD) relative to healthy controls. Twenty-five pwPD and 25 age- and sex-matched healthy controls underwent brain functional MRI (fMRI) during a hand-tapping task: subjects alternatively opened and closed their right hand as fully and quickly as possible. Hand-tapping kinematic parameters were objectively measured during the fMRI task using an optical fibre glove. During the fMRI task, pwPD showed reduced hand-tapping amplitude (hypokinesia) and a greater sequence effect. PwPD relative to healthy controls showed a reduced activity of fronto-parietal areas, middle cingulum/supplementary motor area (SMA), parahippocampus, pallidum/thalamus and motor cerebellar areas. Moreover, pwPD showed an increased activity of brain cognitive areas such as superior temporal gyrus, posterior cingulum, and cerebellum crus I. The decreased activity of cerebellum IV-V-VI, vermis IV-V, inferior frontal gyrus, and cingulum/SMA correlated with hypokinesia and with the sequence effect. Interestingly, a reduced activity of areas involved in motor planning and timing correlated both with hypokinesia and with the sequence effect in pwPD. This study has the major strength of collecting objective motor parameters and brain activity simultaneously, providing a unique opportunity to investigate the neural correlates of the "bradykinesia complex".
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Registered trials
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