ArticleNature communications2024
Simultaneous construction of inherent and axial chirality by cobalt-catalyzed enantioselective C-H activation of calix[4]arenes.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Remote desymmetrization of tetraoxacalix[2]arene[2]triazines enables the asymmetric synthesis of inherently chiral heteracalix[4]aromatics.Chemical science · 2026Article
- Cobalt-Catalyzed Asymmetric Construction of Boron Stereocenters With C-N Axial Chirality.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Organocatalytic Enantioselective Divergent Synthesis of Pillar[5]Arenes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Article
- Installing Axial Chirality by Atroposelective C(spJournal of the American Chemical Society · 2026Article
- Enantioselective synthesis of calix[4]arenes with C-C axial and inherent chiralityChemical science · 2026Article
- Solvent-free and green synthesis of fused pyrimidine derivatives catalyzed by pillar[5]arene-based Lewis acid ionic liquid.Scientific reports · 2026Article
- Recent Advances in the Synthesis of C-N/N-N Atropisomers via Asymmetric Annulation.Topics in current chemistry (Cham) · 2026Review
- Desymmetric esterification catalysed by bifunctional chiral N-heterocyclic carbenes provides access to inherently chiral calix[4]arenes.Nature communications · 2025Article
- Catalytic enantioselective synthesis of inherently chiral calix[4]arenes via organocatalyzed aromatic amination enabled desymmetrization.Nature communications · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The simultaneous construction of multiple stereogenic elements in a single step is highly appealing and desirable in the field of asymmetric synthesis. Furthermore, the catalytic enantioselective synthesis of inherently chiral calix[n]arenes with high enantiopurity has long been a challenging endeavor. Herein, we report an enantioselective cobalt-catalyzed C-H activation/annulation for the efficient construction of inherently chiral calix[4]arenes bearing multiple C-N axially chiral element. By employing the benzamide tethered calix[4]arene as the substrate, the C-H annulation with alkynes can be successfully accomplished, leading to the generation of multiple stereogenic elements. A wide range of calix[4]arenes and alkynes are found to be well compatible, and exhibit good yields, high enantioselectivity and excellent diastereoselectivity. Notably, the gram-scale reaction, catalytic application, synthetic transformations, and chiral recognition further showcase the potential applications of this protocol.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.