Evidence map›Paper›PMID 39242510›Full record

ArticleBMC neurology2024

Mirror movements in multiple sclerosis -a clinical, electrophysiological, and imaging study.

Korbinian Holzapfel, Antonios Bayas, Markus Naumann, Tanupriya Ghosh, Verena Steuerwald, Martin Allweyer, Jan S Kirschke, Lars Behrens

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PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Korbinian HolzapfelDepartment of Neurology and Clinical Neurophysiology, Medical Faculty, University of Augsburg, Augsburg, Germany. korbinian.holzapfel@uk-augsburg.de.
Antonios BayasDepartment of Neurology and Clinical Neurophysiology, Medical Faculty, University of Augsburg, Augsburg, Germany.
Markus NaumannDepartment of Neurology and Clinical Neurophysiology, Medical Faculty, University of Augsburg, Augsburg, Germany.
Tanupriya GhoshDepartment of Neurology and Clinical Neurophysiology, Medical Faculty, University of Augsburg, Augsburg, Germany.
Verena SteuerwaldDepartment of Neurology and Clinical Neurophysiology, Medical Faculty, University of Augsburg, Augsburg, Germany.
Martin AllweyerDepartment of Neurology and Clinical Neurophysiology, Medical Faculty, University of Augsburg, Augsburg, Germany.
Jan S KirschkeDepartment of Neuroradiology, Faculty of Medicine, Technical University of Munich, Munich, Germany.
Lars BehrensDepartment of Diagnostic and Interventional Neuroradiology, Medical Faculty, University of Augsburg, Augsburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMirror movements (MM) are commonly caused by a defect of interhemispheric pathways also affected in multiple sclerosis (MS), particularly the corpus callosum. We investigated the prevalence of MM in MS in relation to functional and morphological callosal fiber integrity by transcranial magnetic stimulation (TMS), magnetic resonance imaging (MRI), as well as fatigue.

methodsIn 21 patients with relapsing-remitting MS and 19 healthy controls, MM were assessed and graded (Woods and Teuber scale: MM 1-4) using a bedside test. Fatigue was evaluated using the Fatigue Scale for Motor and Cognitive Functions (FSMC) questionnaire. TMS measured ipsilateral silent period latency and duration. MRI assessed callosal atrophy by measuring the normalized corpus callosum area (nCCA), corpus callosum index (CCI), and lesion volume.

resultsMS patients had significantly more often and pronounced MM compared to healthy controls (p = 0.0002) and nCCA was significantly lower (p = 0.045) in MRI studies. Patients with higher MM scores (MM > 1 vs. MM 0/1) showed significantly more fatigue (higher FSMC sum score, p = 0.04, motor score, p = 0.01). In TMS and MRI studies, no significant differences were found between patients with MM 0/1 and those with MM > 1 (ipsilateral silent period measurements, CCA, CCI and lesion volume).

conclusionsMM are common in MS and can easily be detected through bedside testing. As MM are associated with fatigue, they might indicate fatigue in MS. It is possible that other cerebral structures, in addition to the corpus callosum, may contribute to the origin of MM in MS.

Indexed as

Corpus CallosumMagnetic Resonance ImagingTranscranial Magnetic StimulationAdultFatigueFemaleHumansMaleMiddle AgedMultiple SclerosisMultiple Sclerosis, Relapsing-RemittingFatigueMagnetic resonance imagingMirror movementsMultiple sclerosisSilent period

Identifiers

PMID39242510
PMCPMC11378473

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