Evidence map›Paper›PMID 39242421›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2025

Indocyanine green fluorescence video-angiography for flap perfusion assessment in head and neck reconstruction: a prospective study.

Andrea Galli, Emilio Salerno, Chiara Bramati, Rosa Alessia Battista, Michela Nicole Melegatti, Elisa Dolfato, Gabriella Fusca, Carlo Pettirossi, Vittorio Gioffré, Marco Familiari and 5 more

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Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Andrea GalliDepartment of Otorhinolaryngology - Head and Neck Surgery, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan, 20132, Italy. agalli89@gmail.com.ORCID http://orcid.org/0000-0003-2677-8091
Emilio SalernoVita-Salute San Raffaele University, Via Olgettina 58, Milan, 20132, Italy.ORCID http://orcid.org/0000-0003-4702-2090
Chiara BramatiDepartment of Otorhinolaryngology, Department of Surgery, ASST Bergamo Ovest, Treviglio, Italy.ORCID http://orcid.org/0000-0002-0765-781X
Rosa Alessia BattistaDepartment of Otorhinolaryngology - Head and Neck Surgery, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan, 20132, Italy.ORCID http://orcid.org/0000-0002-2391-2008
Michela Nicole MelegattiDepartment of Otorhinolaryngology, Head and Neck Surgery, ASST Lariana, Como, Italy.ORCID http://orcid.org/0000-0002-9890-0079
Elisa DolfatoUniversity of Milan, Milan, Italy.
Gabriella FuscaUniversity of Milan, Milan, Italy.
Carlo PettirossiVita-Salute San Raffaele University, Via Olgettina 58, Milan, 20132, Italy.
Vittorio GioffréVita-Salute San Raffaele University, Via Olgettina 58, Milan, 20132, Italy.
Marco FamiliariASST Milano Nord, Milan, Italy.ORCID http://orcid.org/0000-0002-9763-3183
Diego BarbieriDepartment of Otorhinolaryngology - Head and Neck Surgery, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan, 20132, Italy.
Pietro IndelicatoDepartment of Otorhinolaryngology - Head and Neck Surgery, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan, 20132, Italy.ORCID http://orcid.org/0000-0001-7447-0994
Aurora MirabileDepartment of Medical Oncology, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan, 20132, Italy.
Mario BussiDepartment of Otorhinolaryngology - Head and Neck Surgery, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan, 20132, Italy.ORCID http://orcid.org/0000-0003-0192-0194
Leone GiordanoDepartment of Otorhinolaryngology - Head and Neck Surgery, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan, 20132, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeManaging postoperative complications is crucial in reconstructive surgery. Indocyanine green fluorescence video-angiography (ICGA) aids in assessing flap vascularization intraoperatively, potentially reducing complications.

methodsAn ambispective study enrolled head and neck cancer patients undergoing ablative surgery with soft tissue reconstruction. An experimental arm (March 2021-May 2023) used ICGA, while a control arm (January 2017-December 2020) did not. Complications were graded by Clavien-Dindo classification. We also evaluated the effect of systemic inflammation on the sensitivity of ICGA in detecting hypoperfused areas of the flap.

resultsComplications were less frequent in the experimental arm, both overall (11.4% vs. 36.4%) and major ones (Clavien-Dindo ≥ 3) (8.6% vs. 30.9%). ICGA showed a protective effect in univariate and multivariate analyses. Previous radiation and ICGA were independent predictors of major complications. ICGA altered the surgical strategy in 25.7% of cases.

conclusionsReal-time perfusion assessment, particularly with ICGA, can improve outcomes in head and neck cancer patients undergoing soft tissue reconstruction by reducing complications. Further research with larger cohorts is warranted for validation.

Indexed as

Fluorescein AngiographyHead and Neck NeoplasmsIndocyanine GreenPlastic Surgery ProceduresPostoperative ComplicationsSurgical FlapsAdultAgedColoring AgentsFemaleHumansMaleMiddle AgedProspective StudiesColoring AgentsIndocyanine GreenAngiographyComplicationsFlapFluorescenceIndocyanine

Identifiers

PMID39242421

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.