Evidence map›Paper›PMID 39242398›Full record

ArticleEuropean radiology2025

Percutaneous recanalization of non-cirrhotic extrahepatic portal vein obstruction in children: technical considerations in a preliminary cohort.

Paolo Marra, Stephanie Franchi-Abella, José A Hernandez, Maxime Ronot, Riccardo Muglia, Lorenzo D'Antiga, Sandro Sironi

Abstract read
In one paragraph

Article in European radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Long-Term Outcomes of Extrahepatic Portal Vein Obstruction-A Nationwide Registry-Based Follow-Up Study From 1987 to 2023.Liver international : official journal of the International Association for the Study of the Liver · 2026
    Article
  6. Article
  7. Article
  8. Intervention in the Native and Transplant Liver in Children: An Update.Cardiovascular and interventional radiology · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Paolo MarraDepartment of Radiology, ASST Papa Giovanni XXIII Hospital, School of Medicine and Surgery, University of Milano Bicocca, Bergamo, Italy. pmarra@asst-pg23.it.ORCID http://orcid.org/0000-0003-4935-8110
Stephanie Franchi-AbellaDepartment of Pediatric Radiology, DMU Smart Imaging, Bicêtre Hospital, AP-HP. Reference Centre for Vascular Diseases of the Liver, FSMR FILFOIE, ERN RARE LIVER, FHU Hépatinov, Le Kremlin-Bicêtre, France.
José A HernandezDepartment of Interventional Radiology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.
Maxime RonotService de Radiologie, Hôpital Beaujon APHP Nord, Clichy & Université Paris Cité, CRI, INSERM, Paris, France.
Riccardo MugliaDepartment of Radiology, ASST Papa Giovanni XXIII Hospital, School of Medicine and Surgery, University of Milano Bicocca, Bergamo, Italy.
Lorenzo D'AntigaPediatric Hepatology, Gastroenterology and Transplantation, ASST Papa Giovanni XXIII Hospital, Bergamo, Italy.
Sandro SironiDepartment of Radiology, ASST Papa Giovanni XXIII Hospital, School of Medicine and Surgery, University of Milano Bicocca, Bergamo, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesPortal hypertension resulting from non-cirrhotic extrahepatic portal vein obstruction (EHPVO) in children has been primarily managed with the Meso-Rex bypass, but only a few patients have a viable Rex recessus, required by surgery. This study reports a preliminary series of patients who underwent interventional radiology attempts at portal vein recanalization (PVR), with a focus on technical aspects and safety.

methodsA retrospective review of consecutive patients with severe portal hypertension due to non-cirrhotic EHPVO at a single institution from 2022, who underwent percutaneous attempts at PVR, was performed. Technical and clinical data including fluoroscopy time, radiation exposure, technical and clinical success, complications and follow-up were recorded.

resultsEleven patients (6 males and 5 females; median age 7 years, range 1-14) underwent 15 percutaneous transhepatic (n = 1), transplenic (n = 11), or simultaneous transhepatic/transplenic (n = 3) procedures. Rex recessus was patent in 4/11 (36%). Fluoroscopy resulted in a high median total dose area product (DAP) of 123 Gycm

conclusionOur preliminary experience suggests that 45% of children with non-cirrhotic EHPVO can restore portal flow even with obliterated Rex recessus. In non-cirrhotic EHPVO, PVR may be an option, if a Meso-Rex bypass is not feasible, although the radiation exposure deserves attention. CLINICAL RELEVANCE STATEMENT: Innovative percutaneous procedures may have the potential to be an alternative option to the traditional surgical approach in the management of non-cirrhotic EHPVO and its complications in children not eligible for Meso-Rex bypass surgery. KEY POINTS: Non-cirrhotic portal hypertension in children has been traditionally managed by surgery with Meso-Rex bypass creation. Percutaneous PVR may restore the patency of the native portal system even when the Rex recessus is obliterated and surgery has been excluded. Interventional radiological techniques may offer a minimally invasive solution in complex cases of EHPVO in children when Meso-Rex bypass is not feasible.

Indexed as

Hypertension, PortalPortal VeinRadiography, InterventionalAdolescentChildChild, PreschoolFemaleFluoroscopyHumansInfantMaleRetrospective StudiesTreatment OutcomeExtrahepatic portal vein obstructionMeso-Rex bypassPortal hypertensionPortal vein recanalizationPortal vein thrombosis

Identifiers

PMID39242398
PMCPMC12081556

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.