Evidence map›Paper›PMID 39242384›Full record

ReviewResults and problems in cell differentiation2024

Mechanisms of Intracellular Communication in Cancer and Pathogen Spreading.

Silvana Valdebenito, David Ajasin, Karl Valerdi, Yue Ran Liu, Samvrit Rao, Eliseo A Eugenin

Abstract readReview
PubMed Publisher
In one paragraph

Review in Results and problems in cell differentiation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Silvana Valdebenito *Department of Neurobiology, The University of Texas Medical Branch (UTMB), Galveston, TX, USA.
David Ajasin *Department of Neurobiology, The University of Texas Medical Branch (UTMB), Galveston, TX, USA.
Karl ValerdiDepartment of Neurobiology, The University of Texas Medical Branch (UTMB), Galveston, TX, USA.
Yue Ran LiuCornell University, Ithaca, NY, USA.
Samvrit RaoThomas Jefferson High School for Science and Technology, Alexandria, VA, USA.
Eliseo A EugeninDepartment of Neurobiology, The University of Texas Medical Branch (UTMB), Galveston, TX, USA. eleugeni@utmb.edu.

Funding

Role of pannexin-1 hemichannels in NeuroAIDSR01NS105584 · NINDS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI EUGENIN, ELISEO A · 2017 to 2021
$3.2M
Metabolic strategies to eliminate CNS Myeloid Viral ReservoirsR01MH128082 · NIMH · UNIVERSITY OF TEXAS MED BR GALVESTON · PI EUGENIN, ELISEO A · 2021 to 2025
$3.1M
Targeting cell-to-cell communication to prevent bystander damage mediated by viral reservoirsR01MH134761 · NIMH · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Eliseo A Eugenin · 2024 to 2026
$2.1M
NIMH NIH HHS R01 MH128082NIMH NIH HHS R01 MH134761NINDS NIH HHS R01 NS105584
6 · The paper itself

Abstract

Cell-to-cell interactions are essential for proper development, homeostasis, and complex syncytia/organ formation and function. Intercellular communication are mediated by multiple mechanisms including soluble mediators, adhesion molecules and specific mechanisms of cell to cell communication such as Gap junctions (GJ), tunneling nanotubes (TNT), and exosomes. Only recently, has been discovered that TNTs and exosomes enable the exchange of large signaling molecules, RNA, viral products, antigens, and organelles opening new avenues of research and therapeutic approaches. The focus of this review is to summarize these recent findings in physiologic and pathologic conditions.

Indexed as

Cell CommunicationNeoplasmsAnimalsExosomesGap JunctionsHumans

Identifiers

PMID39242384

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.