Evidence map›Paper›PMID 39242369›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025

Effect of MR-guided perfusion imaging mismatch profiles within 6 h on endovascular thrombectomy outcomes.

Xiaohui Li, Zhaomin Lu, Shuo Li, Lin Zhu, Teng Jiang, Huiling Sun, Yuqin Pan, Junshan Zhou, Qiwen Deng

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Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiaohui Li *Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China.
Zhaomin Lu *Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China.
Shuo Li *Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China.
Lin ZhuDepartment of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China.
Teng JiangDepartment of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China.
Huiling SunGeneral Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China.
Yuqin PanGeneral Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China. panyuqin01@163.com.
Junshan ZhouDepartment of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China. zhjsh333@126.com.
Qiwen DengDepartment of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China. qiw_deng@njmu.edu.cn.ORCID http://orcid.org/0000-0003-4324-8009

Funding

Graduate Research and Innovation Projects of Jiangsu Province ZDA2020019
6 · The paper itself

Abstract

backgroundThe treatment of acute ischemic stroke (AIS) aims to achieve early vascular recanalization and reperfusion of the penumbra. However, the effect of early penumbral imaging within 6 h on clinical outcomes remains unclear. The objective of this study was to determine the effect of magnetic resonance-guided (MR-guided) perfusion imaging within 6 h after symptom onset on endovascular thrombectomy outcomes in AIS patients.

methodsWe prospectively collected the clinical information of consecutive AIS patients undergoing endovascular thrombectomy based on MR-guided perfusion imaging within 6 h after symptom onset from AISRNA and EVTRNA studies. The primary outcome was defined as the poor outcome (mRS > 2 within 90 days). The perfusion-weighted imaging/diffusion-weighted imaging (PWI/DWI) mismatch was assessed by an automated software.

resultsWe enrolled 84 patients (25 in the mismatch ≤ 1.8 group and 59 in the mismatch > 1.8 group). Significant difference was found between the mismatch > 1.8 group and the mismatch ≤ 1.8 group for the incidence of disabling stroke (mRS > 2) within 90 days (40.7% vs. 68.0%, OR: 3.099, 95% CI: 1.154-8.323, P = 0.025). Intracranial hemorrhage occurred in 8 patients (13.6%) in the mismatch > 1.8 group and 10 patients in the mismatch ≤ 1.8 group (40.0%) (P = 0.010). The risk of severe cerebral edema was 2/59 (3.4%) vs. 7/25 (28.0%) (P = 0.004). These findings remained stable after adjustment.

conclusionsMR-guided perfusion imaging mismatch profiles within 6 h after symptom onset may be feasible to predictclinical outcomes and reduce clinically ineffective reperfusion after endovascular thrombectomy.

Indexed as

Endovascular ProceduresIschemic StrokeThrombectomyAgedAged, 80 and overDiffusion Magnetic Resonance ImagingFemaleHumansMaleMiddle AgedPerfusion ImagingProspective StudiesTime FactorsTreatment OutcomeAcute ischemic strokeClinical outcomeEndovascular thrombectomyMismatchMR-guided perfusion imaging

Identifiers

PMID39242369

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.