Evidence map›Paper›PMID 39242359›Full record

ArticleJournal of the American Geriatrics Society2025

Association of nursing home antipsychotic reduction policies with antipsychotic use in community dwellers with dementia.

Antoinette B Coe, Tingting Zhang, Andrew R Zullo, Lauren B Gerlach, Lori A Daiello, Hiren Varma, Derrick Lo, Richa Joshi, Julie P W Bynum, Theresa I Shireman

Abstract read
In one paragraph

Article in Journal of the American Geriatrics Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Antoinette B CoeDepartment of Clinical Pharmacy, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-5723-0443
Tingting ZhangCenter for Gerontology and Healthcare Research, Brown University School of Public Health, Providence, Rhode Island, USA.
Andrew R ZulloCenter for Gerontology and Healthcare Research, Brown University School of Public Health, Providence, Rhode Island, USA.ORCID 0000-0003-1673-4570
Lauren B GerlachInstitute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0003-1943-0150
Lori A DaielloCenter for Gerontology and Healthcare Research, Brown University School of Public Health, Providence, Rhode Island, USA.
Hiren VarmaCenter for Gerontology and Healthcare Research, Brown University School of Public Health, Providence, Rhode Island, USA.
Derrick LoCenter for Gerontology and Healthcare Research, Brown University School of Public Health, Providence, Rhode Island, USA.
Richa JoshiCenter for Gerontology and Healthcare Research, Brown University School of Public Health, Providence, Rhode Island, USA.
Julie P W BynumInstitute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, Michigan, USA.
Theresa I ShiremanCenter for Gerontology and Healthcare Research, Brown University School of Public Health, Providence, Rhode Island, USA.

Funding

VARIATIONS IN LIFE'S FINAL CHAPTERP01AG027296 · NIA · BROWN UNIVERSITY · PI AMAL N. TRIVEDI · 2007 to 2026
$38.9M
Clinically Significant Drug Interactions among Nursing Home Residents with ADRDR01AG077620 · NIA · BROWN UNIVERSITY · PI Andrew Reis Zullo · 2022 to 2026
$3.5M
Medications and the Risk of Motor Vehicle Crashes in Older AdultsR01AG065722 · NIA · BROWN UNIVERSITY · PI ZULLO, ANDREW REIS · 2020 to 2023
$2.1M
Medicating distress: Use of psychotropic medications among patients with dementia receiving hospice careK23AG066864 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GERLACH, LAUREN BETH · 2021 to 2025
$1.0M
Improving Medication Use and Outcomes in Older Adults with Dementia after Hospitalization: Effectiveness of Medicare ProgramsK08AG071856 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COE, ANTOINETTE BARTOLOTTA · 2021 to 2024
$620k
NIA NIH HHS K08 AG071856NIA NIH HHS K08AG071856NIA NIH HHS K23 AG066864NIA NIH HHS K23AG066864NIA NIH HHS P01 AG027296NIA NIH HHS P01AG027296NIA NIH HHS R01 AG065722NIA NIH HHS R01AG065722NIA NIH HHS R01 AG077620NIA NIH HHS R01AG077620
6 · The paper itself

Abstract

backgroundAntipsychotic and other psychotropic medication use is prevalent among community-dwelling older adults with dementia despite the potential for adverse effects. Two Centers for Medicare & Medicaid Services (CMS) initiatives, the National Partnership to Improve Dementia Care ("the Partnership") and the Five Star Quality Rating System for antipsychotic use reporting, have been successful in reducing antipsychotic use in nursing home residents. We assessed if these initiatives had a spillover effect in antipsychotic and other psychotropic medication use among community dwellers with dementia due to potential overlap in prescribers across settings.

methodsAmong community-dwelling older adults with dementia, we examined psychotropic medication class use (i.e., antipsychotics, antidepressants, anxiolytics, anticonvulsants/mood stabilizers, antidementia) in 2010-2017 Medicare fee-for-service claims using interrupted time series analyses across three periods ("Pre-Partnership": July 1, 2010 to March 31, 2012; "Post-Partnership": April 1, 2012 to January 31, 2015; "Five Star Quality Rating": February 1, 2015 to December 31, 2017).

resultsWe included 1,289,401 community dwellers with dementia contributing 26,609,697 person-months. The mean age was 80 years, most were female (70%), approximately 80% were non-Hispanic Whites, 10% were non-Hispanic Blacks, and 5% were Hispanic ethnicity. Antipsychotic use was declining pre-Partnership (β = -0.06, 95% CI: -0.08, -0.05) and post-Partnership (β = -0.02, 95% CI: -0.02, -0.01). Post-Five Star Quality Rating, antipsychotic use remained stable with a nearly flat slope (β = -0.01, 95% CI: -0.01, 0.00). Anticonvulsant and antidepressant use increased and anxiolytic and antidementia medication use decreased among community-dwelling older adults with dementia.

conclusionsThese two CMS policies on antipsychotic use for nursing home residents were not associated with a spillover effect to community-dwelling older adults with dementia. Strategies to monitor the appropriateness of psychotropic medication use may be warranted for community-dwellers with dementia.

Indexed as

Antipsychotic AgentsDementiaNursing HomesAgedAged, 80 and overFemaleHumansIndependent LivingInterrupted Time Series AnalysisMaleMedicareUnited StatesAntipsychotic AgentsAlzheimer diseaseantipsychoticcommunity‐dwellingdementiapsychotropic drugs

Identifiers

PMID39242359
PMCPMC11734101

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.