Evidence map›Paper›PMID 39242078›Full record

ArticleChest2024

Impact of Dyspnea on Adults With Respiratory Symptoms Without a Defined Diagnosis.

Jared Bierbrier, Emily Gerstein, George A Whitmore, Katherine L Vandemheen, Celine Bergeron, Louis-Philippe Boulet, Andreanne Cote, Stephen K Field, Erika Penz, R Andrew McIvor and 13 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Chest, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Jared BierbrierThe Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
Emily GersteinThe Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
George A WhitmoreDesautels Faculty of Management, McGill University, Montreal, QC, Canada.
Katherine L VandemheenThe Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
Celine BergeronDepartment of Medicine, The University of British Columbia, Vancouver, BC, Canada.
Louis-Philippe BouletCentre de recherche, Institut de cardiologie et de pneumologie de Québec, Université Laval, Quebec, QC, Canada.
Andreanne CoteCentre de recherche, Institut de cardiologie et de pneumologie de Québec, Université Laval, Quebec, QC, Canada.
Stephen K FieldCumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Erika PenzDepartment of Medicine, University of Saskatchewan, Regina, SK, Canada.
R Andrew McIvorFirestone Institute for Respiratory Health, McMaster University, Hamilton, ON, Canada.
Catherine LemièreDepartment of Medicine, Université de Montreal, Montreal, QC, Canada.
Samir GuptaDepartment of Medicine and the Li Ka Shing Knowledge Institute, St. Michael's Hospital University of Toronto, Toronto, ON, Canada.
Paul HernandezDepartment of Medicine, Dalhousie University, Halifax, NS, Canada.
Irvin MayersDepartment of Medicine, University of Alberta, Edmonton, AB, Canada.
Mohit BhutaniDepartment of Medicine, University of Alberta, Edmonton, AB, Canada.
M Diane LougheedDepartment of Medicine, Queen's University, Kingston, ON, Canada.
Christopher J LicskaiDepartment of Medicine, University of Western Ontario, London, ON, Canada.
Tanweer AzherDepartment of Medicine, Memorial University, St. John's, Newfoundland, NL, Canada.
Nicole EzerDepartment of Medicine, McGill University, Montreal, QC, Canada.
Martha AinslieDepartment of Medicine, University of Manitoba, Winnipeg, MB, Canada.
Gonzalo G AlvarezThe Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
Sunita MulpuruThe Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
Shawn D AaronThe Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada. Electronic address: saaron@ohri.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe investigated dyspnea; its associated risk factors; and its impact on health care utilization, quality of life, and work productivity in adults with undiagnosed respiratory symptoms. RESEARCH QUESTION: What is the impact of dyspnea in adults with undiagnosed respiratory symptoms? STUDY DESIGN AND

methodsThis population-based study included 2,857 adults who were experiencing respiratory symptoms. These individuals had not been previously diagnosed with any lung conditions and were recruited from 17 Canadian centers using random digit dialing. Each participant underwent spirometry testing both before and after using a bronchodilator to determine if they met the diagnostic criteria for COPD, asthma, or preserved ratio impaired spirometry (PRISm), or if their spirometry results were normal. An age-matched control group (n = 231) was similarly recruited using random digit dialing. A dyspnea impact assessment score from 0 to 100 was produced using questions from the COPD Assessment Test and St. George's Respiratory questionnaire.

resultsIndividuals with PRISm (n = 172) reported more impactful dyspnea (mean score, 63.0; 95% CI, 59.5-66.4) than those with undiagnosed asthma (n = 265; mean score, 56.6; 95% CI, 53.9-59.3) or undiagnosed COPD (n = 330; mean score, 57.5; 95% CI, 55.1-59.9). All groups reported significantly more impactful dyspnea than the control group (mean score, 13.8; 95% CI, 11.8-15.7). Patient-specific risk factors including age, sex, BMI, smoking, and comorbidities explained 20.6% of the variation in dyspnea. An additional 12.4% of the variation was explained by disease classification and another 1.7% by the severity of lung function impairment assessed with spirometry. After adjusting for age, sex, and BMI, greater dyspnea impact was associated with increased health care utilization, lower quality of life, and reduced work productivity.

interpretationOur findings showed that in community-based adults with undiagnosed respiratory symptoms, those identified with PRISm experienced the greatest impact of dyspnea. Dyspnea imposes burdens on the health care system and is associated with impaired quality of life and work productivity.

Indexed as

AsthmaDyspneaPulmonary Disease, Chronic ObstructiveQuality of LifeSpirometryAdultAgedCanadaFemaleHumansMaleMiddle AgedRisk FactorsSurveys and Questionnairesasthmacase findingCOPDdyspnea

Identifiers

PMID39242078
PMCPMC11638540

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.