Evidence map›Paper›PMID 39242020›Full record

ArticleResuscitation2024

Temporal trends in organ donation among cardiac arrest patients treated with extracorporeal cardiopulmonary resuscitation.

Despoina Koukousaki, Marinos Kosmopoulos, John Mallow, Pierre S Sebastian, Christopher Monti, Alejandra Gutierrez, Andrea Elliott, Rajat Kalra, Sergey Gurevich, Tamas Alexy and 4 more

Abstract read
In one paragraph

Article in Resuscitation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Despoina KoukousakiUniversity of Minnesota Medical School, Department of Medicine, Division of Cardiology, Center for Resuscitation Medicine, MN, USA.
Marinos KosmopoulosUniversity of Minnesota Medical School, Department of Medicine, Division of Cardiology, Center for Resuscitation Medicine, MN, USA.
John MallowUniversity of Minnesota Medical School, Department of Medicine, Division of Cardiology, Center for Resuscitation Medicine, MN, USA.
Pierre S SebastianUniversity of California, San Francisco, Department of Medicine, CA, USA.
Christopher MontiMedical College of Wisconsin, Milwaukee, WI, USA.
Alejandra GutierrezUniversity of Minnesota Medical School, Department of Medicine, Division of Cardiology, Center for Resuscitation Medicine, MN, USA.
Andrea ElliottUniversity of Minnesota Medical School, Department of Medicine, Division of Cardiology, Center for Resuscitation Medicine, MN, USA.
Rajat KalraUniversity of Minnesota Medical School, Department of Medicine, Division of Cardiology, Center for Resuscitation Medicine, MN, USA.
Sergey GurevichUniversity of Minnesota Medical School, Department of Medicine, Division of Cardiology, Center for Resuscitation Medicine, MN, USA.
Tamas AlexyUniversity of Minnesota Medical School, Department of Medicine, Division of Cardiology, Center for Resuscitation Medicine, MN, USA.
Charles BruenRegions Hospital, Health Partners, St. Paul, MN, USA.
Varvara KirchnerDivision of Abdominal Transplantation, Department of Surgery, Stanford University, Stanford, CA, USA.
Jason A BartosUniversity of Minnesota Medical School, Department of Medicine, Division of Cardiology, Center for Resuscitation Medicine, MN, USA.
Demetris YannopoulosUniversity of Minnesota Medical School, Department of Medicine, Division of Cardiology, Center for Resuscitation Medicine, MN, USA. Electronic address: yanno001@umn.edu.

Funding

Advanced REperfusion STrategies- The ARREST TrialR33HL142696 · NHLBI · UNIVERSITY OF MINNESOTA · PI AUFDERHEIDE, TOM PAUL, YANNOPOULOS, DEMETRIS · 2019 to 2020
$1.3M
Advanced REperfusion STrategies- The ARREST TrialR61HL142696 · NHLBI · UNIVERSITY OF MINNESOTA · PI AUFDERHEIDE, TOM PAUL, YANNOPOULOS, DEMETRIS · 2018 to 2018
$750k
American Heart Association-American Stroke Association 23TPA1140962NHLBI NIH HHS R33 HL142696NHLBI NIH HHS R61 HL142696
6 · The paper itself

Abstract

aimsThis study explores the evolution of organ donation from patients treated with extracorporeal-cardiopulmonary-resuscitation (ECPR) for refractory out-of-hospital-cardiac-arrest (OHCA) and evaluates the public health benefits of a mature ECPR program.

methodsThis retrospective, single-center study included OHCA patients (2016-2023) who had mostly initial shockable rhythms and were treated with ECPR. Organ donation rates from non-survivors through these years were analyzed. The public health benefit of ECPR was determined by the ratio of the sum of survivors with Cerebral Performance Category 1-2 and non-survivors who donated at least 1 solid organ, to the total ECPR patients. Temporal trends were analyzed yearly using linear regression.

resultsOut of 419 ECPR patients presenting with refractory OHCA over the study period, 116 survived neurologically intact (27.7%). Among non-survivors (n = 303), families of 41 (13.5%) consented to organ donation (median age 51 years, 75.6% male) and organs from 38 patients were harvested, leading to 74 organ transplants to 73 recipients. The transplanted organs included 43 kidneys (58.1%), 27 livers (36.5%), 3 lungs (4%), and 1 heart (1.4%), averaging 2.4 ± 0.9 accepted organs/donor. The number of organ donors and successful transplants correlated positively with the years since the ECPR program's initiation (p

conclusionThe public health benefits of an established ECPR program extend beyond individual ECPR patient survival, forming a new, previously under-recognized source of transplant donors.

Indexed as

Cardiopulmonary ResuscitationExtracorporeal Membrane OxygenationOut-of-Hospital Cardiac ArrestTissue and Organ ProcurementAdultAgedFemaleHumansMaleMiddle AgedRetrospective StudiesTissue DonorsCardiac arrestECPROrgan donation

Identifiers

PMID39242020
PMCPMC12681980

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.