ArticleCancer cell2024
Integrated electrophysiological and genomic profiles of single cells reveal spiking tumor cells in human glioma.
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Article in Cancer cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29citing papers in PubMed
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Who cites it
29 citing papers in PubMed.
- Neuro-immune interactions in tumors, immune-related disorders, and infections.Signal transduction and targeted therapy · 2026Review
- Imaging strategies for delineating glioma margins: Aiming at precise therapy.Fundamental research · 2026Review
- Observation of Acetylcholine Secretion on Living Glioblastoma Cells.ACS measurement science au · 2026Article
- Hp1bp3 loss links chromatin reorganization to metabolic vulnerability in glioma.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Spatial and single-cell characterization of human glioblastoma tumor microenvironment reveals malignant cellular communities.Nature neuroscience · 2026Article
- Combined patch-clamp electrophysiology and single-cell genomic analysis reveal spiking tumor cells at the neocortical glioblastoma interface in humans.Neuro-oncology · 2026Article
- Neuro-glioma activity-dependent growth mechanisms: an actionable circuit from NLGN3-ADAM10 to AMPA synapses.Translational cancer research · 2026Review
- Ligand-Receptor Interaction Combined with Histopathology Improves Glioma Prognostic Model.Biomedicines · 2026Article
- Leveraging neuroscience imaging and electrophysiological assessments to decode neuron-glioma interactions.Neuro-oncology advances · 2026Review
- Article
- Regulation of tumor proliferation by unlocking silent synapses on metastatic cancer cells.bioRxiv : the preprint server for biology · 2026Article
- The double-positive cells in the tumor microenvironment.Journal of translational internal medicine · 2026Article
- Targeting ion channel dysregulation in tumors: emerging therapeutic opportunities.Trends in pharmacological sciences · 2026Review
- Increased neural excitability and glioma synaptic activity drives glioma proliferation in human cortex.Nature neuroscience · 2026Article
- Critical role of cell competition in gliomagenesis.bioRxiv : the preprint server for biology · 2026Article
- Functional implications of atypical action potential generation in the (patho)physiological brain: from developmental program to glioma.Frontiers in neural circuits · 2026Review
- Diversity and function of tumor-associated macrophages in brain metastases: mechanisms and therapeutic prospects.Frontiers in immunology · 2026Review
- CulturedBrain communications · 2026Article
- Pharmacological targeting and characterization of Voltage-Gated Sodium Channels (VGSCs) expressed in the high-grade glioma microenvironment.BMC cancer · 2025Article
- Aberrant neural activity in the peritumoral cortex underlies the progression of tumor-associated seizures.Nature communications · 2025Article
Corrections and comments
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Authors and funding
17 authors.
Rachel N CurryThe Integrative Molecular and Biomedical Sciences Graduate Program, Baylor College of Medicine, Houston, TX, USA; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.
Qianqian MaJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, USA; Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA.
Malcolm F McDonaldCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA; Medical Scientist Training Program, Baylor College of Medicine, Houston, TX, USA; Program in Development, Disease Models, and Therapeutics, Baylor College of Medicine, Houston, TX, USA.
Yeunjung KoCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA; Center for Cancer Neuroscience, Baylor College of Medicine, Houston, TX, USA; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.
Snigdha SrivastavaJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, USA; Medical Scientist Training Program, Baylor College of Medicine, Houston, TX, USA; Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, TX, USA.
Pey-Shyuan ChinDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, USA.
Peihao HeCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA; Center for Cancer Neuroscience, Baylor College of Medicine, Houston, TX, USA; Program in Cancer Cell Biology, Baylor College of Medicine, Houston, TX, USA.
Brittney LozziProgram in Genetics and Genomics, Baylor College of Medicine, Houston, TX, USA.
Prazwal AthukuriDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.
Junzhan JingJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, USA; Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA.
Su WangDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.
Arif O HarmanciMcWilliams School of Biomedical Informatics, University of Texas Health Science Center, Houston, TX, USA.
Benjamin ArenkielDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, USA; Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, TX, USA.
Xiaolong JiangJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, USA; Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA; Department of Ophthalmology, Baylor College of Medicine, Houston, TX, USA. Electronic address: xiaolonj@bcm.edu.
Benjamin DeneenThe Integrative Molecular and Biomedical Sciences Graduate Program, Baylor College of Medicine, Houston, TX, USA; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA; Program in Development, Disease Models, and Therapeutics, Baylor College of Medicine, Houston, TX, USA; Center for Cancer Neuroscience, Baylor College of Medicine, Houston, TX, USA; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA; Program in Cancer Cell Biology, Baylor College of Medicine, Houston, TX, USA. Electronic address: deneen@bcm.edu.
Ganesh RaoCenter for Cancer Neuroscience, Baylor College of Medicine, Houston, TX, USA; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA. Electronic address: grao@bcm.edu.
Akdes Serin HarmanciCenter for Cancer Neuroscience, Baylor College of Medicine, Houston, TX, USA; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA. Electronic address: akdes.serinharmanci@bcm.edu.
Funding
VISION RESEARCH CENTERP30EY002520 · NEI · BAYLOR COLLEGE OF MEDICINE · PI Samuel M Wu · 1985 to 2026
$14.8MTraining In Cell and Gene TherapyT32HL092332 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI MALCOLM K. BRENNER, Bruno Di Stefano · 2008 to 2026
$6.9MModulation of Microglia and T Cell Interactions in Malignant GliomaR01CA120813 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI HEIMBERGER, AMY BETH, RAO, GANESH · 2007 to 2025
$4.7MSystematic Characterization and Targeting of Neomorphic Drivers in CancerU01CA281902 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Benjamin Deneen, Han Liang · 2023 to 2026
$3.5MMOLECULAR DISSECTION OF SEIZURE MICROENVIRONMENT IN MALIGNANT GLIOMAR01CA223388 · NCI · BAYLOR COLLEGE OF MEDICINE · PI DENEEN, BENJAMIN, NOEBELS, JEFFREY · 2018 to 2022
$3.5MAstrocyte Transcriptional Dependencies in Brain CircuitsR35NS132230 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI Benjamin Deneen · 2023 to 2026
$3.5MDevelopment of aberrant cortical interneuron circuitry in genetic mouse models of absence epilepsyR01NS110767 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI JIANG, XIAOLONG, NOEBELS, JEFFREY · 2020 to 2024
$2.2MDeciphering the building blocks of the macaque prefrontal cortical microcircuitR01MH120404 · NIMH · BAYLOR COLLEGE OF MEDICINE · PI JIANG, XIAOLONG · 2019 to 2023
$2.0MMulti-Cellular Analysis of the Retinal NetworkR01EY033492 · NEI · BAYLOR COLLEGE OF MEDICINE · PI Xiaolong Jiang, Samuel M Wu · 2022 to 2026
$2.0MMODELING MALIGNANT PROGRESSION IN GLIOMAR01NS094615 · NINDS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI RAO, GANESH · 2016 to 2020
$1.8MCellular and Molecular Mechanisms of GBM InfiltrationR01NS124093 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI Benjamin Deneen, Ganesh Rao · 2022 to 2026
$1.6MDeciphering the transcriptomic signatures, physiology, and connectivity of the specialized morphotypes in macaque insular cortexR01MH122169 · NIMH · BAYLOR COLLEGE OF MEDICINE · PI JIANG, XIAOLONG · 2020 to 2024
$1.2MNCI NIH HHS F31 CA265156NCI NIH HHS F99 CA274700NCI NIH HHS K00 CA274700NCI NIH HHS R01 CA223388NCI NIH HHS U01 CA281902NEI NIH HHS P30 EY002520NEI NIH HHS R01 EY033492NHLBI NIH HHS T32 HL092332NIH HHS S10 OD023469NIH HHS S10 OD025240NIMH NIH HHS R01 MH120404NIMH NIH HHS R01 MH122169NINDS NIH HHS R01 NS094615NINDS NIH HHS R01 NS110767NINDS NIH HHS R01 NS124093NINDS NIH HHS R35 NS132230
Abstract
Prior studies have described the complex interplay that exists between glioma cells and neurons; however, the electrophysiological properties endogenous to glioma cells remain obscure. To address this, we employed Patch-sequencing (Patch-seq) on human glioma specimens and found that one-third of patched cells in IDH mutant (IDH
Indexed as
Action PotentialsBrain NeoplasmsGliomaSingle-Cell AnalysisElectrophysiological PhenomenaGABAergic NeuronsGenomicsHumansIsocitrate DehydrogenaseMutationTranscriptomeIsocitrate Dehydrogenaseaction potentialsGABAergic neuronsgliomamachine learningoligodendrocyte precursor cellsPatch-seqscRNA-seq
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.