Evidence map›Paper›PMID 39241777›Full record

ArticleCurrent biology : CB2024

Reverse-engineering placebo analgesia.

Bin Chen, Nitsan Goldstein, Julia Dziubek, Akili Sundai, Shengli Zhao, Andrew Harrahill, Seonmi Choi, Vincent Prevosto, Fan Wang

Abstract read
In one paragraph

Article in Current biology : CB, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Convergent state-control of endogenous opioid analgesia.bioRxiv : the preprint server for biology · 2025
    Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Bin ChenMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 43 Vassar Street, Cambridge, MA 02139, USA.
Nitsan GoldsteinMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 43 Vassar Street, Cambridge, MA 02139, USA.
Julia DziubekMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 43 Vassar Street, Cambridge, MA 02139, USA.
Akili SundaiMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 43 Vassar Street, Cambridge, MA 02139, USA.
Shengli ZhaoDepartment of Neurobiology, Duke University Medical Center, 311 Research Drive, Durham, NC 27710, USA.
Andrew HarrahillMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 43 Vassar Street, Cambridge, MA 02139, USA.
Seonmi ChoiMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 43 Vassar Street, Cambridge, MA 02139, USA.
Vincent PrevostoMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 43 Vassar Street, Cambridge, MA 02139, USA. Electronic address: prevosto@mit.edu.
Fan WangMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 43 Vassar Street, Cambridge, MA 02139, USA. Electronic address: fan_wang@mit.edu.

Funding

Identification and Validation of a Novel Central Analgesia CircuitR01DE029342 · NIDCR · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI MATHEW, JOSEPH P, WANG, FAN · 2019 to 2019
$2.9M
NIDCR NIH HHS R01 DE029342
6 · The paper itself

Abstract

Placebo analgesia is a widely observed clinical phenomenon. Establishing a robust mouse model of placebo analgesia is needed for careful dissection of the underpinning circuit mechanisms. However, previous studies failed to observe consistent placebo effects in rodent models of chronic pain. We wondered whether strong placebo analgesia can be reverse engineered using general-anesthesia-activated neurons in the central amygdala (CeA

Indexed as

AnalgesiaAnimalsCentral Amygdaloid NucleusChronic PainMaleMiceMice, Inbred C57BLNeuronsPain ManagementPlacebo Effectacute painanesthesiaassociative learningcentral amygdalachronic painplacebo analgesia

Identifiers

PMID39241777
PMCPMC12093384

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.