Evidence map›Paper›PMID 39241774›Full record

ArticleCell reports. Medicine2024

Detecting altered hepatic lipid oxidation by MRI in an animal model of MASLD.

Marc McLeod, Mario C Chang, Anna Rushin, Mukundan Ragavan, Rohit Mahar, Gaurav Sharma, Arshee Badar, Anthony Giacalone, Max E Glanz, Vinay R Malut and 5 more

Abstract read
In one paragraph

Article in Cell reports. Medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Deuterated pH Probes Based on Ketoglutarate for Magnetic Resonance.Journal of the American Chemical Society · 2026
    Article
  4. Article
  5. Hyperpolarized [U-ACS chemical biology · 2026
    Article
  6. MASH: the nexus of metabolism, inflammation, and fibrosis.The Journal of clinical investigation · 2025
    Review
  7. Article
  8. Antioxidant andPlants (Basel, Switzerland) · 2025
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Marc McLeodDepartment of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL 32610, USA; University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9014, USA.
Mario C ChangDepartment of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL 32610, USA.
Anna RushinDepartment of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL 32610, USA.
Mukundan RagavanDepartment of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL 32610, USA; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Rohit MaharDepartment of Chemistry, Hemvati Nandan Bahuguna Garhwal University (A Central University), Srinagar Garhwal, Uttarakhand 246174, India.
Gaurav SharmaDepartment of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL 32610, USA.
Arshee BadarDepartment of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL 32610, USA.
Anthony GiacaloneDepartment of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL 32610, USA.
Max E GlanzDepartment of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL 32610, USA.
Vinay R MalutDepartment of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL 32610, USA.
Dalton GrahamDepartment of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL 32610, USA.
Nishanth E SunnyDepartment of Animal and Avian Sciences, University of Maryland, College Park, MD 20742, USA.
James A BanksonDepartment of Imaging Physics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030-4009, USA.
Kenneth CusiDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Veterans Health Administration and University of Florida, Gainesville, FL 32610, USA.
Matthew E MerrittDepartment of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL 32610, USA. Electronic address: matthewmerritt@ufl.edu.

Funding

HDO Imaging is a Quantitative Marker of Cerebral Glucose OxidationR01EB032376 · NIBIB · UNIVERSITY OF FLORIDA · PI BANKSON, JAMES A, KODIBAGKAR, VIKRAM D. · 2022 to 2025
$2.2M
Imaging Hepatic Energy Metabolism in NAFLD/NASHR01DK132254 · NIDDK · UNIVERSITY OF FLORIDA · PI MERRITT, MATTHEW E · 2022 to 2025
$2.0M
Interdisciplinary Graduate Program in Type 1 Diabetes and Biomedical EngineeringT32DK108736 · NIDDK · UNIVERSITY OF FLORIDA · PI MARK A. ATKINSON, Benjamin George Keselowsky · 2017 to 2026
$1.9M
Metabolic Origins of Nonalcoholic SteatohepatitisR01DK112865 · NIDDK · UNIV OF MARYLAND, COLLEGE PARK · PI SUNNY, NISHANTH · 2017 to 2021
$1.8M
Upgrade of an 11T/40cm MRI/S SystemS10RR025671 · NCRR · UNIVERSITY OF FLORIDA · PI EDISON, ARTHUR S · 2009 to 2009
$500k
Console upgrade for microimaging and solid state NMR spectroscopy at 600 MHzS10RR031637 · NCRR · UNIVERSITY OF FLORIDA · PI LONG, JOANNA R · 2011 to 2011
$450k
NCRR NIH HHS S10 RR025671NCRR NIH HHS S10 RR031637NIBIB NIH HHS R01 EB032376NIDDK NIH HHS R01 DK112865NIDDK NIH HHS R01 DK132254NIDDK NIH HHS T32 DK108736
6 · The paper itself

Abstract

Metabolic dysfunction-associated steatotic liver disease (MASLD) prevalence is increasing annually and affects over a third of US adults. MASLD can progress to metabolic dysfunction-associated steatohepatitis (MASH), characterized by severe hepatocyte injury, inflammation, and eventual advanced fibrosis or cirrhosis. MASH is predicted to become the primary cause of liver transplant by 2030. Although the etiology of MASLD/MASH is incompletely understood, dysregulated fatty acid oxidation is implicated in disease pathogenesis. Here, we develop a method for estimating hepatic β-oxidation from the metabolism of [D

Indexed as

Disease Models, AnimalFatty LiverLipid MetabolismLiverMagnetic Resonance ImagingOxidation-ReductionAnimalsDiet, High-FatFatty AcidsMaleMiceMice, Inbred C57BLFatty Acidsdeuterium MRIMASLDmetabolic fluxoctanoatesteatosisX-nucleus imagingβ-oxidation

Identifiers

PMID39241774
PMCPMC11525016

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.