Evidence map›Paper›PMID 39241536›Full record

ArticleJournal of autoimmunity2024

Lupus-prone NZM2328 mice exhibit enhanced UV-induced myeloid cell recruitment and activation in a type I interferon dependent manner.

Mitra P Maz, Alayka L Reddy, Celine C Berthier, Lam C Tsoi, Deborah J Colesa, Sonya J Wolf, Hong Shi, Shannon N Loftus, Rezvan Moallemian, Rachael Bogle and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of autoimmunity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Mitra P MazDiv. of Rheumatology, Dept. of Internal Medicine, University of Michigan, Ann Arbor, MI, USA; Medical Scientist Training Program, University of Michigan, Ann Arbor, MI, USA; Immunology Graduate Program, University of Michigan, Ann Arbor, MI, USA.
Alayka L ReddyDiv. of Rheumatology, Dept. of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Celine C BerthierDiv. of Nephrology, Dept. of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Lam C TsoiDepartment of Dermatology, University of Michigan, Ann Arbor, MI, USA.
Deborah J ColesaDiv. of Rheumatology, Dept. of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Sonya J WolfDiv. of Rheumatology, Dept. of Internal Medicine, University of Michigan, Ann Arbor, MI, USA; Immunology Graduate Program, University of Michigan, Ann Arbor, MI, USA.
Hong ShiDiv. of Rheumatology, Dept. of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Shannon N LoftusDiv. of Rheumatology, Dept. of Internal Medicine, University of Michigan, Ann Arbor, MI, USA; Immunology Graduate Program, University of Michigan, Ann Arbor, MI, USA.
Rezvan MoallemianDiv. of Rheumatology, Dept. of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Rachael BogleDepartment of Dermatology, University of Michigan, Ann Arbor, MI, USA.
Matthias KretzlerDiv. of Nephrology, Dept. of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Chaim O JacobUniversity of Southern California Keck School of Medicine, Los Angeles, CA, USA.
Johann E GudjonssonDiv. of Rheumatology, Dept. of Internal Medicine, University of Michigan, Ann Arbor, MI, USA; Department of Dermatology, University of Michigan, Ann Arbor, MI, USA.
J Michelle KahlenbergDiv. of Rheumatology, Dept. of Internal Medicine, University of Michigan, Ann Arbor, MI, USA; Department of Dermatology, University of Michigan, Ann Arbor, MI, USA. Electronic address: mkahlenb@med.umich.edu.

Funding

University of Michigan O'Brien Kidney Translational Core CenterP30DK081943 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BROSIUS, FRANK C · 2008 to 2022
$12.9M
University of Michigan Skin Biology and Diseases Resource-based CenterP30AR075043 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Johann Eli Gudjonsson · 2019 to 2026
$6.6M
Characterization of Interferon Kappa as a Novel Target in Cutaneous LupusR01AR071384 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Joanne Michelle Kahlenberg · 2017 to 2026
$3.6M
Linking Disease Mechanisms and Outcomes in Rheumatic DiseasesK24AR076975 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Joanne Michelle Kahlenberg · 2020 to 2026
$910k
NIAMS NIH HHS K24 AR076975NIAMS NIH HHS P30 AR075043NIAMS NIH HHS R01 AR071384NIDDK NIH HHS P30 DK081943
6 · The paper itself

Abstract

Though the exact causes of systemic lupus erythematosus (SLE) remain unknown, exposure to ultraviolet (UV) light is one of the few well-known triggers of cutaneous inflammation in SLE. However, the precise cell types which contribute to the early cutaneous inflammatory response in lupus, and the ways that UV dosing and interferons modulate these findings, have not been thoroughly dissected. Here, we explore these questions using the NZM2328 spontaneous murine model of lupus. In addition, we use iNZM mice, which share the NZM2328 background but harbor a whole-body knockout of the type I interferon (IFN) receptor, and wild-type BALB/c mice. 10-13-week-old female mice of each strain were treated with acute (300 mJ/cm

Indexed as

Disease Models, AnimalInterferon Type ILupus Erythematosus, SystemicMyeloid CellsUltraviolet RaysAnimalsFemaleMiceMice, Inbred BALB CMice, KnockoutReceptor, Interferon alpha-betaSkinInterferon Type IReceptor, Interferon alpha-betaInterferonMyeloid cellsSystemic lupusUltraviolet light

Identifiers

PMID39241536
PMCPMC12557466

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.