Evidence map›Paper›PMID 39241506›Full record

ArticleParkinsonism & related disorders2024

Lifetime physical activity influences Parkinson's disease progression.

Yang Cheng Hu, Cynthia D J Kusters, Kimberly C Paul, Aline Duarte Folle, Keren Zhang, I-Fan Shih, Adrienne M Keener, Jeff M Bronstein, Beate R Ritz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parkinsonism & related disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Observational
  2. Review
  3. Lifestyle medicine in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yang Cheng HuDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA.
Cynthia D J KustersDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA; Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, Los Angeles, CA, USA; Jane and Terry Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA.
Kimberly C PaulDepartment of Neurology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA.
Aline Duarte FolleDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA.
Keren ZhangDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA.
I-Fan ShihDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA.
Adrienne M KeenerDepartment of Neurology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA; Parkinson's Disease Research, Education, and Clinical Center, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
Jeff M BronsteinDepartment of Neurology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA.
Beate R RitzDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA; Department of Neurology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA; Department of Environmental Health Sciences, UCLA Fielding School of Public Health, Los Angeles, CA, USA. Electronic address: britz@ucla.edu.

Funding

UCLA CENTER FOR THE STUDY OF PARKINSON'S DISEASEP50NS038367 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHESSELET, MARIE-FRANCOISE S · 1999 to 2011
$15.3M
Center for Gene-Environment Studies in Parkinson DiseaseU54ES012078 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHESSELET, MARIE-FRANCOISE S · 2002 to 2006
$7.1M
Project 4: Pesticides and Genes In PD: Studies In HumansP01ES016732 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RITZ, BEATE R. · 2008 to 2012
$6.7M
PARKINSON'S DISEASES SUSCEPTIBILITY GENES AND PESTICIDESR01ES010544 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RITZ, BEATE R. · 2000 to 2015
$5.7M
Environmental exposure, DNA methylation, and Parkinson's diseaseR21ES024356 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HORVATH, STEVE, RITZ, BEATE R. · 2014 to 2015
$424k
NIEHS NIH HHS P01 ES016732NIEHS NIH HHS R01 ES010544NIEHS NIH HHS R21 ES024356NIEHS NIH HHS U54 ES012078NINDS NIH HHS P50 NS038367
6 · The paper itself

Abstract

introductionPast studies suggested that Parkinson's disease (PD) patients who engage in physical activity (PA) after diagnosis have slower motor progression. Here, we examine the influence of lifetime PA prior to PD onset on motor, cognitive, and overall functional decline among PD patients.

methodsFor 495 participants in the Parkinson's Environment and Gene (PEG) studies, we collected PA-related measures through interviews and quantified these using metabolic equivalents (MET) scores. PD progression was defined as time to a Unified Parkinson's Disease Rating Scale Part III (UPDRS-III) conversion to ≥ 35 points, Hoehn and Yahr (H&Y) ≥ 3, and a 4-point decline in Mini-Mental State Examination (MMSE). We used Cox frailty models to estimate hazard ratios and inverse probability weights to account for heterogeneity by enrollment wave and censoring.

resultsFor PD patients reporting the highest lifetime strenuous MET-h/wk (highest quartile), we estimated a lower HR for time-to-UPDRS-III-conversion (Q4 vs. Q1: HR = 0.56, 95 % CI = [0.36, 0.87]). Additionally, having engaged in any competitive sport also reduced the risk of reaching a UPDRS-III ≥ 35 points (low vs. none: HR = 0.61, 95 % CI = [0.44, 0.86]; high vs. none: HR = 0.63; 95 % CI = [0.44,0.86]); high levels of sports activities also affected progression on the H&Y scale (high vs. none: HR = 0.73; 95 % CI = [0.46,1.00]). Lifetime PA measures did not affect time-to-MMSE decline.

conclusionOur study suggests that PD patients who engaged in higher levels of lifetime strenuous PA and competitive sports prior to PD diagnosis experience slower motor and overall functional decline, suggesting that lifetime PA may contribute to a physical reserve advantageous for PD patients.

Indexed as

Disease ProgressionExerciseParkinson DiseaseAgedCognitive DysfunctionFemaleHumansMaleMiddle AgedExerciseParkinson's diseasePhysical activityProgressionTime-to-event analysis

Identifiers

PMID39241506
PMCPMC12320786

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.