ArticleProceedings of the National Academy of Sciences of the United States of America2024
Plasma cell-free RNA signatures of inflammatory syndromes in children.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed.
- Correlation between the coronary computed tomography angiography-derived pericoronary fat attenuation index and coronary artery lesions in Kawasaki disease.Quantitative imaging in medicine and surgery · 2026Article
- Benchmarking large language models for cell-free RNA diagnostic biomarker discovery.Nature communications · 2026Article
- Artificial intelligence in respiratory medicine: From diagnosis to treatment and future directions.Chinese medical journal pulmonary and critical care medicine · 2026Review
- Multisystem inflammatory syndrome in children is a SARS-CoV-2 triggered Kawasaki disease.Pediatric research · 2026Observational
- Cell-free RNA reveals host and microbial correlates of broadly neutralizing antibody development against HIV.PLoS pathogens · 2026Article
- Cell-free DNA methylome and fragmentome analysis for relapse monitoring of Ewing sarcoma.EMBO molecular medicine · 2026Article
- Cell-free RNA Signatures Derived from the Tumor Microenvironment Predict Outcomes of CAR-T Therapy in Large B Cell Lymphoma.medRxiv : the preprint server for health sciences · 2026Article
- Minimal correlation but complementary diagnostic utility for plasma cell-free RNA and proteins.Communications medicine · 2026Article
- Circulating Cell-Free RNA Reflects Immune-Associated and Airway Remodeling Signatures in Equine Asthma.Journal of immunology research · 2026Article
- Clinical metagenomics for diagnosis and surveillance of viral pathogens.Nature reviews. Microbiology · 2026Review
- Red Clover (Trifolium pratense) Isoflavones Reduce Plasma Levels of Extracellular DNA and Histone Proteins in Rats with Experimental Type 2 Diabetes Mellitus.Bulletin of experimental biology and medicine · 2025Article
- Circulating cell-free RNA signatures for the characterization and diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Molecular characterization of Kawasaki disease subgroups using cell-free RNA profiling.Scientific reports · 2025Article
- Plasma cell-free RNA signatures of inflammatory syndromes in children.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
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25 authors.
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Abstract
Inflammatory syndromes, including those caused by infection, are a major cause of hospital admissions among children and are often misdiagnosed because of a lack of advanced molecular diagnostic tools. In this study, we explored the utility of circulating cell-free RNA (cfRNA) in plasma as an analyte for the differential diagnosis and characterization of pediatric inflammatory syndromes. We profiled cfRNA in 370 plasma samples from pediatric patients with a range of inflammatory conditions, including Kawasaki disease (KD), multisystem inflammatory syndrome in children (MIS-C), viral infections, and bacterial infections. We developed machine learning models based on these cfRNA profiles, which effectively differentiated KD from MIS-C-two conditions presenting with overlapping symptoms-with high performance [test area under the curve = 0.98]. We further extended this methodology into a multiclass machine learning framework that achieved 80% accuracy in distinguishing among KD, MIS-C, viral, and bacterial infections. We further demonstrated that cfRNA profiles can be used to quantify injury to specific tissues and organs, including the liver, heart, endothelium, nervous system, and the upper respiratory tract. Overall, this study identified cfRNA as a versatile analyte for the differential diagnosis and characterization of a wide range of pediatric inflammatory syndromes.
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