Evidence map›Paper›PMID 39240516›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2025

Trabecular Meshwork Regeneration for Glaucoma Treatment Using Stem Cell-Derived Trophic Factors.

Ajay Kumar, Enzhi Yang, Yiqin Du

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ajay KumarDepartment of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, USA.
Enzhi YangDepartment of Ophthalmology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Yiqin DuDepartment of Ophthalmology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA. yiqindu@usf.edu.

Funding

Mechanisms of Trabecular Meshwork Regeneration by Stem CellsR01EY025643 · NEI · UNIVERSITY OF SOUTH FLORIDA · PI Yiqin Du · 2015 to 2026
$4.2M
NEI NIH HHS R01 EY025643
6 · The paper itself

Abstract

Glaucoma is one of the leading causes of irreversible blindness. Stem cell therapy has shown promise in the treatment of primary open-angle glaucoma in animal models. Stem cell-free therapy using stem cell-derived trophic factors might be in demand in patients with high-risk conditions or religious restrictions. In this chapter, we describe methods for trabecular meshwork stem cell (TMSC) cultivation, secretome harvesting, and protein isolation, as well as assays to ensure the health of TMSC post-secretome harvesting and for secretome periocular injection into mice for therapeutic purposes.

Indexed as

Stem CellsTrabecular MeshworkAnimalsCell Culture TechniquesCells, CulturedDisease Models, AnimalGlaucomaGlaucoma, Open-AngleHumansIntercellular Signaling Peptides and ProteinsMiceRegenerationSecretomeStem Cell TransplantationIntercellular Signaling Peptides and ProteinsGlaucomaPeriocular injectionSecretomeStem cellsTrabecular meshwork

Identifiers

PMID39240516
PMCPMC11971979

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.