Evidence map›Paper›PMID 39240418›Full record

ReviewInfection2025

Lautropia mirabilis sepsis in immunodeficiency: first report and genomic features.

Svea Genseke, Mirjeta Berisha, Aljoscha Teerstegen, Björn Meyer, Achim J Kaasch, Jacqueline Färber, Enrico Schalk, Andreas E Zautner, Torben Esser, Sascha Kahlfuß

Abstract readCase ReportsReview
PubMed Publisher
In one paragraph

Review in Infection, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Svea GensekeMedical Faculty, Institute of Medical Microbiology and Hospital Hygiene, Otto von Guericke University Magdeburg, Magdeburg, Germany.
Mirjeta BerishaMedical Faculty, Department of Hematology, Oncology and Cell Therapy, Otto von Guericke University Magdeburg, Magdeburg, Germany.ORCID http://orcid.org/0000-0001-5625-7858
Aljoscha TeerstegenMedical Faculty, Institute of Medical Microbiology and Hospital Hygiene, Otto von Guericke University Magdeburg, Magdeburg, Germany.
Björn MeyerMedical Faculty, Institute of Medical Microbiology and Hospital Hygiene, Otto von Guericke University Magdeburg, Magdeburg, Germany.ORCID http://orcid.org/0000-0002-7903-5710
Achim J KaaschMedical Faculty, Institute of Medical Microbiology and Hospital Hygiene, Otto von Guericke University Magdeburg, Magdeburg, Germany.ORCID http://orcid.org/0000-0002-6659-6738
Jacqueline FärberMedical Faculty, Institute of Medical Microbiology and Hospital Hygiene, Otto von Guericke University Magdeburg, Magdeburg, Germany.
Enrico SchalkMedical Faculty, Department of Hematology, Oncology and Cell Therapy, Otto von Guericke University Magdeburg, Magdeburg, Germany.ORCID http://orcid.org/0000-0003-1892-5098
Andreas E ZautnerMedical Faculty, Institute of Medical Microbiology and Hospital Hygiene, Otto von Guericke University Magdeburg, Magdeburg, Germany. azautne@gwdg.de.ORCID http://orcid.org/0000-0003-0984-013X
Torben EsserMedical Faculty, Institute of Medical Microbiology and Hospital Hygiene, Otto von Guericke University Magdeburg, Magdeburg, Germany. torben.esser@med.ovgu.de.
Sascha KahlfußMedical Faculty, Institute of Medical Microbiology and Hospital Hygiene, Otto von Guericke University Magdeburg, Magdeburg, Germany. sascha.kahlfuss@med.ovgu.de.ORCID http://orcid.org/0000-0001-8813-1061

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeLautropia mirabilis is a Gram-negative, facultative anaerobic coccus, which has been detected mainly in respiratory sites of immunodeficient patients suffering from HIV or cystic fibrosis. To date, knowledge about the pathogenicity of L. mirabilis is spare due to the small numbers of documented cases.

methodsWe present a literature review and report the case of a 39-year-old female diagnosed with common variable immunodeficiency (CVID) with IgG and IgA deficiency suffering from a sepsis with L. mirabilis. As no fully closed L. mirabilis genome besides the type strain was available to date, we additionally performed complete genome sequencing of L. mirabilis.

resultsThe patient was admitted to our hospital with recurrent episodes of fever. Here, we detected L. mirabilis in two different blood cultures. The bacterium was tested susceptible to and treated with meropenem. As the origin of L. mirabilis sepsis, we observed an active periodontitis likely due to impaired IgA levels and mucosal insufficiency as a consequence of CVID. Whole genome sequencing of L. mirabilis revealed several genes important for host cell invasion and intracellular survival of the pathogen.

conclusionsOur case highlights the importance of L. mirabilis in immunocompromised patients also in other compartments than the respiratory tract.

Indexed as

Common Variable ImmunodeficiencySepsisAdultAnti-Bacterial AgentsFemaleGenome, BacterialHumansImmunocompromised HostWhole Genome SequencingAnti-Bacterial AgentsBacteremiaCVIDImmunodeficiencyInfectionLautropia mirabilisSepsis

Identifiers

PMID39240418

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.