Evidence map›Paper›PMID 39240397›Full record

ReviewSeminars in immunopathology2024

Role of Hyaluronic acid and its chemical derivatives in immunity during homeostasis, cancer and tissue regeneration.

Paolo Rosales, Daiana Vitale, Antonella Icardi, Ina Sevic, Laura Alaniz

Abstract readReview
PubMed Publisher
In one paragraph

Review in Seminars in immunopathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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  16. Advances in hyaluronic acid hydrogel for meniscus repair.Frontiers in bioengineering and biotechnology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Paolo RosalesLaboratorio de Microambiente Tumoral, CIBA, UNNOBA/ CIT NOBA (UNNOBA-UNSADA- CONICET), Jorge Newbery 261, Junín, 6000, Bs. As, Argentina.ORCID 0000-0002-1923-569X
Daiana VitaleLaboratorio de Microambiente Tumoral, CIBA, UNNOBA/ CIT NOBA (UNNOBA-UNSADA- CONICET), Jorge Newbery 261, Junín, 6000, Bs. As, Argentina.ORCID 0000-0001-5593-9101
Antonella IcardiLaboratorio de Microambiente Tumoral, CIBA, UNNOBA/ CIT NOBA (UNNOBA-UNSADA- CONICET), Jorge Newbery 261, Junín, 6000, Bs. As, Argentina.ORCID 0000-0002-3768-830X
Ina SevicLaboratorio de Microambiente Tumoral, CIBA, UNNOBA/ CIT NOBA (UNNOBA-UNSADA- CONICET), Jorge Newbery 261, Junín, 6000, Bs. As, Argentina.ORCID 0000-0002-4920-5096
Laura AlanizLaboratorio de Microambiente Tumoral, CIBA, UNNOBA/ CIT NOBA (UNNOBA-UNSADA- CONICET), Jorge Newbery 261, Junín, 6000, Bs. As, Argentina. ldalaniz@comunidad.unnoba.edu.ar.ORCID 0000-0002-6070-6078

Funding

PICT 2021-I-A-01060PICT 2021-I-INVI-00793SIB UNNOBA 2082/2022
6 · The paper itself

Abstract

Over the last few decades, scientists have recognized the critical role that various components of the extracellular matrix (ECM) play in maintaining homeostatic immunity. Besides, dysregulation in the synthesis or degradation levels of these components directly impacts the mechanisms of immune response during tissue injury caused by tumor processes or the regeneration of the tissue itself in the event of damage. ECM is a complex network of protein compounds, proteoglycans and glycosaminoglycans (GAGs). Hyaluronic acid (HA) is one of the major GAGs of this network, whose metabolism is strictly physiologically regulated and quickly altered in injury processes, affecting the behavior of different cells, from stem cells to differentiated immune cells. In this revision we discuss how the native or chemically modified HA interacts with its specific receptors and modulates intra and intercellular communication of immune cells, focusing on cancer and tissue regeneration conditions.

Indexed as

HomeostasisHyaluronic AcidNeoplasmsRegenerationAnimalsExtracellular MatrixHumansImmunityHyaluronic AcidCancerHyaluronic acid (HA)ImmunityTissue regenerationTumor microenvironment (TME)

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.