Evidence map›Paper›PMID 39240395›Full record

ArticleAnnals of surgical oncology2024

Evaluating the Efficacy of Different Treatment Intensities in Nasopharyngeal Carcinoma Patients: A Nationwide Cancer Registry-Based Study.

Chung-Wen Jen, Han-Ching Chan, Chun-Ju Chiang, Wen-Chung Lee, Tzu-Pin Lu, Skye Hung-Chun Cheng

Abstract read
PubMed Publisher
In one paragraph

Article in Annals of surgical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chung-Wen JenInstitute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei City, Taiwan.
Han-Ching ChanInstitute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei City, Taiwan.
Chun-Ju ChiangInstitute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei City, Taiwan.
Wen-Chung LeeInstitute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei City, Taiwan.
Tzu-Pin LuInstitute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei City, Taiwan. tplu@ntu.edu.tw.
Skye Hung-Chun ChengDepartment of Radiation Oncology, Taitung Christian Hospital, Taitung City, Taitung County, Taiwan. skyecheng@gmail.com.

Funding

Health Promotion Administration, Ministry of Health and Welfare 112KKZA3T1Ministry of Science and Technology, Taiwan MOST109-2314-B-002-151-MY3Research and Development Center for Medical Devices, National Taiwan University 112KKZA3T1
6 · The paper itself

Abstract

objectiveThe aim of this study was to evaluate the efficacy of different treatment intensities (TIs) in patients with nasopharyngeal carcinoma (NPC).

methodsThe study assessed newly diagnosed, non-metastatic NPC patients from the Taiwan Cancer Registry between 2010 and 2017. TIs were divided into four groups: TI1 [radiotherapy (RT) alone or induction chemotherapy (IC) followed by RT); TI2 (concurrent chemoradiotherapy (CRT) alone); TI3 (IC followed by CRT or CRT followed by adjuvant chemotherapy (AC)]; and TI4 (IC followed by CRT followed by AC). The primary outcome was cancer-specific survival (CSS).

resultsThe study included 9863 patients. For stage I-II NPC patients, there was no significant difference in CSS among the different TI groups. For stage III patients, those receiving TI3 had better CSS (hazard ratio [HR] 0.69) compared with those receiving TI1. No significant differences in CSS were noted among those receiving TI2, TI3, and TI4. For stage IVA-B patients, those receiving TI2 (HR 0.70), TI3 (HR 0.49), and TI4 (HR 0.43) had better CSS compared with those receiving TI1. Compared with stage IVA-B patients receiving TI2, those receiving TI3 (HR 0.70) and TI4 (HR 0.61) had significantly better CSS. No differences in CSS were noted between those receiving TI3 and TI4.

conclusionsFor stage I-II NPC patients, RT alone is appropriate. For stage III and IVA-B patients, IC + CRT or CRT + AC may be needed to achieve optimal outcomes. No advantage of IC + CRT + AC over IC + CRT or CRT + AC was observed.

Indexed as

ChemoradiotherapyNasopharyngeal CarcinomaNasopharyngeal NeoplasmsRegistriesAdultAgedAntineoplastic Combined Chemotherapy ProtocolsChemotherapy, AdjuvantCombined Modality TherapyFemaleFollow-Up StudiesHumansInduction ChemotherapyMaleMiddle AgedNeoplasm StagingAdjuvant chemotherapyConcurrent chemoradiotherapyInduction chemotherapyNasopharyngeal carcinomaRadiotherapy

Identifiers

PMID39240395

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.