Evidence map›Paper›PMID 39240376›Full record

ReviewArchives of dermatological research2024

The brain-skin axis in vitiligo.

Cheng Cao, Jindi Lei, Yujie Zheng, Ai'e Xu, Miaoni Zhou

Abstract readReview
PubMed Publisher
In one paragraph

Review in Archives of dermatological research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Cheng CaoSchool of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Jindi LeiSchool of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Yujie ZhengSchool of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Ai'e XuDepartment of Dermatology, Hangzhou Third Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, China.
Miaoni ZhouDepartment of Dermatology, Hangzhou Third Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, China. zhoumiaoni@163.com.

Funding

Natural Science Foundation of Zhejiang Province ZCLY24H1101Zhejiang Chinese Medicine University Postgraduate Scientific Research Fund Project No.2023YKJ11
6 · The paper itself

Abstract

Vitiligo is an acquired autoimmune skin disease characterized by patchy depigmentation of the skin, often accompanied by white hair. The aetiology of vitiligo is complex and difficult to cure, and its disfiguring appearance significantly impacts patients' mental and physical health. Psychological stress is a major factor in inducing and exacerbating vitiligo, as well as affecting its treatment efficacy, though the specific mechanisms remain unclear. Increasing research on the brain-skin axis in skin immunity suggests that psychological stress can influence local skin immunity through this axis, which may play a crucial role in the pathogenesis of vitiligo. This review focuses on the role of brain-skin axis in the pathogenesis of vitiligo, and explores the possible mechanism of brain-skin axis mediating the pathogenesis of vitiligo from the aspects of sympathetic nervous system, hypothalamic-pituitary-adrenal (HPA) axis and hormones and neuropeptides, aiming to provide the necessary theoretical basis for psychological intervention in the prevention and treatment of vitiligo.

Indexed as

Hypothalamo-Hypophyseal SystemPituitary-Adrenal SystemSkinStress, PsychologicalVitiligoBrainHumansNeuropeptidesSympathetic Nervous SystemNeuropeptidesBrain-skin axisPsychological stressSympathetic nervous systemVitiligo

Identifiers

PMID39240376

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.