Evidence map›Paper›PMID 39240258›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2024

Heart failure with preserved ejection fraction in pigs causes shifts in posttranscriptional checkpoints.

Stephanie L Samani, Shayne C Barlow, Lisa A Freeburg, Grayson M Catherwood, Amelia M Churillo, Traci L Jones, Diego Altomare, Hao Ji, Michael Shtutman, Michael R Zile and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Diffuse Myocardial Fibrosis: Can We Reverse Course?JACC. Basic to translational science · 2025
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Stephanie L SamaniCell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina, United States.
Shayne C BarlowCell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina, United States.ORCID 0000-0003-1679-176X
Lisa A FreeburgCell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina, United States.
Grayson M CatherwoodCell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina, United States.
Amelia M ChurilloCell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina, United States.
Traci L JonesCell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina, United States.ORCID 0009-0002-7827-3079
Diego AltomareDrug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, South Carolina, United States.ORCID 0000-0002-9126-5703
Hao JiDrug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, South Carolina, United States.ORCID 0009-0005-5667-5861
Michael ShtutmanDrug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, South Carolina, United States.ORCID 0000-0002-2458-3226
Michael R ZileDivision of Cardiology, Ralph H. Johnson Department of Veterans Affairs Medical Center, Medical University of South Carolina, Charleston, South Carolina, United States.
Tarek ShazlyCollege of Engineering and Computing, University of South Carolina, Columbia, South Carolina, United States.
Francis G SpinaleCell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina, United States.ORCID 0000-0003-0529-5605

Funding

Targeting NMDA Receptors and Brain Estradiol to Rescue Memory in Aging FemalesP20GM109091 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI RONINSON, IGOR B · 2014 to 2024
$25.2M
Image Guided Delivery of Bioresponsive HydrogelsR01HL137365 · NHLBI · YALE UNIVERSITY · PI BURDICK, JASON A, DUNCAN, JAMES S · 2018 to 2021
$3.2M
Proteolytic Imaging of Remodeling MyocardiumR42HL131280 · NHLBI · MICRO VIDE, LLC · PI SPINALE, FRANCIS G · 2016 to 2018
$1.8M
Maladaptive Remodeling in Aging MyocardiumI01BX000168 · VA · VETERANS HEALTH ADMINISTRATION · PI SPINALE, FRANCIS G · 2009 to 2024
–
Myocardial Plasticity in Heart Failure with Preserved Ejection Fraction (HFpEF)I01BX005320 · VA · VETERANS HEALTH ADMINISTRATION · PI SPINALE, FRANCIS G · 2022 to 2025
–
BLRD VA I01 BX000168BLRD VA I01 BX005320HHS | National Institutes of Health (NIH) P20GM109091HHS | National Institutes of Health (NIH) R01HL131280HHS | National Institutes of Health (NIH) R01HL131972HHS | National Institutes of Health (NIH) R01HL13765NHLBI NIH HHS R01 HL137365NHLBI NIH HHS R42 HL131280NIGMS NIH HHS P20 GM109091U.S. Department of Veterans Affairs (VA) 1I01-BX005320U.S. Department of Veterans Affairs (VA) 5I01-BX000168
6 · The paper itself

Abstract

Left ventricular pressure overload (LVPO) can lead to heart failure with a preserved ejection fraction (HFpEF) and LV chamber stiffness (LV

Indexed as

Heart FailureMicroRNAsStroke VolumeVentricular Function, LeftAnimalsDisease Models, AnimalFemaleGene Expression RegulationMaleRNA Processing, Post-TranscriptionalSus scrofaSwineVentricular PressureMicroRNAsLA dilationLV diastolic dysfunctionmicroRNA

Identifiers

PMID39240258
PMCPMC11560071

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.