Evidence map›Paper›PMID 39240256›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2024

Gestational influenza A virus infection elicits nonresolving vascular dysfunction and T-cell accumulation in the aorta of mice.

Osezua Oseghale, Kylie M Quinn, Madison Coward-Smith, Felicia Liong, Mark A Miles, Robert D Brooks, Ross Vlahos, John J O'Leary, Doug A Brooks, Stella Liong and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Osezua OseghaleSchool of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia.ORCID 0000-0001-8661-0990
Kylie M QuinnSchool of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia.ORCID 0000-0002-0417-3625
Madison Coward-SmithSchool of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia.ORCID 0000-0002-5362-8577
Felicia LiongSchool of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia.ORCID 0000-0002-4785-5466
Mark A MilesSchool of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia.
Robert D BrooksClinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.
Ross VlahosSchool of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia.ORCID 0000-0001-8443-7071
John J O'LearyDiscipline of Histopathology, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Ireland.ORCID 0000-0001-7311-9326
Doug A BrooksClinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.ORCID 0000-0001-9098-3626
Stella LiongSchool of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia.ORCID 0000-0001-6131-858X
Stavros SelemidisSchool of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia.ORCID 0000-0002-3989-7615

Funding

DHAC | National Health and Medical Research Council (NHMRC) 1122506DHAC | National Health and Medical Research Council (NHMRC) 1128276DHAC | National Health and Medical Research Council (NHMRC) 2002948
6 · The paper itself

Abstract

T-cell accumulation within the aorta promotes endothelial dysfunction and the genesis of cardiovascular disease, including hypertension and atherosclerosis. Viral infection during pregnancy is also known to mediate marked acute endothelial dysfunction, but it is not clear whether T cells are recruited to the aorta and whether the dysfunction persists postpartum. Here, we demonstrate that influenza A virus (IAV) infection during pregnancy in a murine model resulted in endothelial dysfunction of the aorta, which persisted for up to 60 days postinfection and was associated with higher levels of IFN-γ mRNA expression within the tissue. In the absence of infection, low numbers of naïve CD4

Indexed as

AortaCD8-Positive T-LymphocytesInfluenza A virusInterferon-gammaMice, Inbred C57BLOrthomyxoviridae InfectionsAnimalsCD4-Positive T-LymphocytesDisease Models, AnimalEndothelium, VascularFemaleMemory T CellsMicePregnancyPregnancy Complications, InfectiousIFNG protein, mouseInterferon-gammainfluenzamemory T cellspregnancyvascular dysfunction

Identifiers

PMID39240256
PMCPMC11482285

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.