Evidence map›Paper›PMID 39240253›Full record

ArticleThe Journal of physiology2025

GluN2C/D-containing NMDA receptors enhance temporal summation and increase sound-evoked and spontaneous firing in the inferior colliculus.

Audrey C Drotos, Rachel L Zarb, Victoria Booth, Michael T Roberts

Abstract read
In one paragraph

Article in The Journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Audrey C DrotosDepartment of Otolaryngology - Head and Neck Surgery, Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-5035-9319
Rachel L ZarbDepartment of Otolaryngology - Head and Neck Surgery, Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI, USA.
Victoria BoothDepartment of Mathematics, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-2586-8001
Michael T RobertsDepartment of Otolaryngology - Head and Neck Surgery, Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-2835-8752

Funding

Circuit Mechanisms for Auditory Processing in the Inferior ColliculusR01DC018284 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ROBERTS, MICHAEL THOMAS · 2020 to 2024
$2.3M
Mechanisms Shaping Temporal Integration in the Inferior ColliculusF31DC021344 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DROTOS, AUDREY CLAIRE · 2023 to 2024
$62k
NIDCD NIH HHS F31 DC021344NIDCD NIH HHS R01 DC018284
6 · The paper itself

Abstract

Along the ascending auditory pathway, there is a broad shift from temporal coding, which is common in the lower auditory brainstem, to rate coding, which predominates in auditory cortex. This temporal-to-rate transition is particularly prominent in the inferior colliculus (IC), the midbrain hub of the auditory system, but the mechanisms that govern how individual IC neurons integrate information across time remain largely unknown. Here, we report the widespread expression of Glun2c and Glun2d mRNA in IC neurons. GluN2C/D-containing NMDA receptors are relatively insensitive to voltage-dependent Mg

Indexed as

Action PotentialsInferior ColliculiNeuronsReceptors, N-Methyl-D-AspartateAnimalsFemaleMaleMiceMice, Inbred C57BLVasoactive Intestinal PeptideNR2C NMDA receptorNR2D NMDA receptorReceptors, N-Methyl-D-AspartateVasoactive Intestinal Peptideauditory systemelectrophysiologyexcitatory synaptic transmissioninferior colliculusmodellingNMDA receptorsynaptic integration

Identifiers

PMID39240253
PMCPMC11882938

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.