Evidence map›Paper›PMID 39240242›Full record

ArticleChemSusChem2025

On the Valorisation of Chitin-Derived Furans by Milling.

Renan Rodini Mattioli, Camila Souza Santos, Bruna Butke de Souza, Pedro Dominguez Branco, Robert R A Bolt, Sarah E Raby-Buck, Tadeu Luiz Gomes Cabral, Claudio F Tormena, Duncan L Browne, Julio C Pastre

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In one paragraph

Article in ChemSusChem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Renan Rodini MattioliInstitute of Chemistry, State University of Campinas (UNICAMP), Campinas, SP, 13083-970, Brazil.
Camila Souza SantosInstitute of Chemistry, State University of Campinas (UNICAMP), Campinas, SP, 13083-970, Brazil.
Bruna Butke de SouzaInstitute of Chemistry, State University of Campinas (UNICAMP), Campinas, SP, 13083-970, Brazil.
Pedro Dominguez BrancoInstitute of Chemistry, State University of Campinas (UNICAMP), Campinas, SP, 13083-970, Brazil.
Robert R A BoltDepartment of Pharmaceutical and Biological Chemistry, School of Pharmacy, University College London (UCL), 29-39 Brunswick Square, London, WC1N 1AX, UK.ORCID https://orcid.org/0000-0002-9721-4931
Sarah E Raby-BuckDepartment of Pharmaceutical and Biological Chemistry, School of Pharmacy, University College London (UCL), 29-39 Brunswick Square, London, WC1N 1AX, UK.ORCID https://orcid.org/0000-0003-2561-3885
Tadeu Luiz Gomes CabralInstitute of Chemistry, State University of Campinas (UNICAMP), Campinas, SP, 13083-970, Brazil.
Claudio F TormenaInstitute of Chemistry, State University of Campinas (UNICAMP), Campinas, SP, 13083-970, Brazil.
Duncan L BrowneDepartment of Pharmaceutical and Biological Chemistry, School of Pharmacy, University College London (UCL), 29-39 Brunswick Square, London, WC1N 1AX, UK.ORCID https://orcid.org/0000-0002-8604-229X
Julio C PastreInstitute of Chemistry, State University of Campinas (UNICAMP), Campinas, SP, 13083-970, Brazil.ORCID https://orcid.org/0000-0001-9972-425X

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 308540/2021-2Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Finance Code 001Fundação de Amparo à Pesquisa do Estado de São Paulo 2019/26450-9Fundação de Amparo à Pesquisa do Estado de São Paulo 2020/10246-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2021/05081-5Fundação de Amparo à Pesquisa do Estado de São Paulo 2021/06661-5Fundação de Amparo à Pesquisa do Estado de São Paulo 2022/00774-5Fundação de Amparo à Pesquisa do Estado de São Paulo 2022/03872-8Fundação de Amparo à Pesquisa do Estado de São Paulo 2023/01232-4Fundação de Amparo à Pesquisa do Estado de São Paulo 2023/01238-2
6 · The paper itself

Abstract

Chitin-derived furans offer a sustainable alternative feedstock for nitrogen appended aromatic compounds. Herein, we address the challenge of using chitin-derived furans, 3-acetamido-5-acetylfuran (3A5AF) and 3-acetamido-5-furfural aldehyde (3A5F), to favour the formation of exo Diels-Alder adducts and 4-acetylaminophthalimides respectively, using a mechanochemical ball-milling technique. Mechanochemical activation is explored through the synthesis of 7-oxa-norbornene backbones with novel substitution pattern from 3A5AF in yields up to 77 % and improved exo:endo selectivity compared to solution-phase reactions. The synthesis of 4-acetylaminophthalimides from 3A5F in yields up to 79 % is also showcased from hydrazone derivatives.

Indexed as

AromaticsChitinDiels–AlderHydrazoneMechanochemistry

Identifiers

PMID39240242
PMCPMC11790004

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.