SynthesisJournal of cosmetic dermatology2024
Meta-Analysis of the Efficacy of Intense Pulsed Light and Pulsed-Dye Laser Therapy in the Management of Rosacea.
Synthesis in Journal of cosmetic dermatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07729540 (Intense Pulsed Light, a Targeted Anti-Redness Dermocosmetic Regimen, and Their Combination for Erythematotelangiectatic Rosacea), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Intense Pulsed Light, a Targeted Anti-Redness Dermocosmetic Regimen, and Their Combination for Erythematotelangiectatic Rosacea: A Comparative Study Using Antera 3D Chromophore Mapping, Grey-Level Co-Occurrence Matrix Texture Analysis and Clinician Erythema Assessment Scale.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Molecular Mechanisms in the Etiopathology of Rosacea-Systematic Review.International journal of molecular sciences · 2025Pooled it
- Real-World Broadband Light Treatment Strategies and Early Treatment Response in Facial Vascular Lesions: A Retrospective Observational Study.Dermatology and therapy · 2026Article
- Rethinking Steroid-Induced Rosacea: Why Vascular Laser Therapy Deserves an Earlier Role.Cureus · 2026Article
- Laser-Based Therapies in Rosacea: A Comprehensive Review of Mechanisms, Clinical Efficacy, and Future Directions.Journal of clinical medicine · 2026Review
- Current Clinical Perspectives on Rosacea Management: Insights From a Korean Multicenter Expert Opinion Survey.Annals of dermatology · 2026Article
- Comparison of the Efficacy and Safety of Pulsed Dye Laser, Intense Pulsed Light and Radiofrequency Therapy in the Treatment of Erythematotelangiectatic Rosacea.Clinical, cosmetic and investigational dermatology · 2026Article
- Assessment of the Degree of Erythema Reduction in Rosacea After Polychromatic Light Treatments.Journal of clinical medicine · 2025Article
- Article
- Plant-derived extracellular vesicles in facial aesthetics.Extracellular vesicles and circulating nucleic acids · 2025Review
- A Case of Intense Pulsed Light Aggravated Rosacea Successfully Treated by Abrocitinib.Clinical, cosmetic and investigational dermatology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe primary aim of this systematic review and meta-analysis was to synthesize and compare the clinical efficacy of intense pulsed light (IPL) and pulsed-dye laser (PDL) therapies for the management of rosacea.
methodsThe literatures were searched in the Web of Science, PubMed, Embase, and Cochrane Library databases to identify relevant studies investigating the use of IPL and PDL for the treatment of rosacea. Screening of the retrieved articles and data extraction were performed as per the pre-established inclusion and exclusion criteria. The primary outcome measures evaluated in this meta-analysis included clearance rates, erythema scores, and pain scores.
resultsThe meta-analysis incorporated data from four studies involving a total of 141 participants. The meta-analysis did not reveal a statistically significant difference between IPL and PDL in the rate of achieving greater than 50% clearance (RR = -0.07, 95% CI: -0.19, 0.05). However, the IPL group demonstrated a significantly higher rate of clearance exceeding 75% compared to the PDL group (RR = -0.13, 95% CI: -0.23, -0.04). The change in erythema index, a key measure of rosacea severity, was similar between the two treatment modalities (SMD = -0.15, 95% CI: -0.55, 0.26). Interestingly, the PDL group reported a notably lower VAS pain score than the IPL group (SMD = 1.54, 95% CI: 0.08, 3.00).
conclusionEither PDL or IPL appears to be effective modalities for the management of rosacea. IPL exhibits a slight advantage in achieving a higher rate of substantial (>75%) clearance, while PDL may be preferable for patients with lower tolerance for post-treatment discomfort. However, the existing literature directly comparing these two laser/light-based therapies is limited, warranting further well-designed, large-scale studies to establish the optimal treatment algorithm for this chronic inflammatory skin condition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.